This isn’t ‘evolution busting’, have to laugh at university PR. The drug has modest single agent activity, and is additive with a chemotherapy drug in an animal model (not synergistic). The mechanism of action is a bit interesting, it seems to make cells rush through the cell cycle. The drug development is going to be complicated. The drug doesn’t work well by itself, so getting the right combination dosing and sched…
I mean, every cancer therapy drug would be 'evolution busting' if this was the case.
This isn’t ‘evolution busting’, have to laugh at university PR. The drug has modest single agent activity, and is additive with a chemotherapy drug in an animal model (not synergistic). The mechanism of action is a bit interesting, it seems to make cells rush through the cell cycle. The drug development is going to be complicated. The drug doesn’t work well by itself, so getting the right combination dosing and sched…
There are even DNA and cell division targeted agents. Colchicine kills cells by messing with DNA segregation between dividing cells. This one appears to promote division? Though I haven’t read all the details.
I think it doesn't promote cell division directly. IIUC this make the cell during the division to not wait until the chromosomes are correctly split, so the new cell have a high chance of getting a wrong number of chromosome and die. Since the cell doesn't wait until everything is in order, the division is faster. Form the abstract: https://mct.aacrjournals.org/content/18/10/1696 > In in vivo pharmacodynamic experime…
Oh interesting. It's basically working in a similar way to Colchicine then. Colchicine blows up the microtubules so the chromosomes don't segregate properly. The combination of the two might be effective, though I suspect there's a toxicity issue or something else I'm missing.