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Evolutionary gene loss may explain why only humans are prone to heart attack

sciencedaily.com

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Re: Evolutionary gene loss may explain why only humans are prone to heart attack

#11

Post by JohnJamesRambo »

watertom wrote: post #10

Linus Pauling figured out almost 30 years ago why humans are prone to heart attacks, and not only did he discover why, he also has a mechanism by which to reverse existing heart disease and prevent heart attacks and strokes. The Pharmaceutical industry ridiculed his solution and tried to discredit his work, claiming that he had become crazy in his old age. Personally I have much more faith in Dr. Pauling than I do in…

I hate to attack your deity but...

https://www.quackwatch.org/01QuackeryRelatedTopics/pauling.h...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5000725/

“Overall, current research suggests that vitamin C deficiency is associated with a higher risk of mortality from CVD and that vitamin C may slightly improve endothelial function and lipid profiles in some groups, especially those with low plasma vitamin C levels. However, the current literature provides little support for the widespread use of vitamin C supplementation to reduce CVD risk or mortality.”

Re: Evolutionary gene loss may explain why only humans are prone to heart attack

#12

Post by deanstag »

dilawar wrote: post #9

I wonder if a gone lost hundreds of years ago is somehow _responsible_, then why heart attack related death mostly occured in last 50 years?

It could be that they were not diagnosed as heart attacks before that.

edit: And also maybe general life style differences regarding availability and richness of food, exercise, shorter life spans etc.

Re: Evolutionary gene loss may explain why only humans are prone to heart attack

#13

Post by segfaultbuserr »

olliej wrote: post #2

I like how the headlines explicitly states humans . For yet another study in ... mice. There are other options like dogs and pigs which are much better models for human biology, so if you really want to make a claim about subtle effects of human genetics you need to be as close to a human model as possible. This is entirely ignoring the someone generous leap they make that one single gene mutation is responsible for…

#JustSayInMice! https://twitter.com/justsaysinmice

* Hyped-up science is a problem. One clever Twitter account is pushing back.

https://www.vox.com/future-perfect/2019/6/15/18679138/nutrit...

Just for some background for those who weren't aware what is the OP all about. But to be fair, I think this article is actually well-written and doesn't contain sensationalized framing.

Re: Evolutionary gene loss may explain why only humans are prone to heart attack

#14

Post by baddox »

fragmede wrote: post #8
crabLouse wrote: post #5

Since the driver of the selection against the related gene seems to be malaria, I wonder if this is linked to prevalence of body hair on human ancestors. Bug bites on hairless skin probably had something to do with dying of disease, and the early homonids that had the gene seem to be the ones hit the hardest. We also see evolutionary markers related to bed bugs, head lice and body lice. Maybe mosquitos and genes link…

Malaria is a fascinating one, with the prevalence of sickle cell anemia and G6PD blood deficiency in some populations with high exposure. Both of those cause health issues but they both confer some level of resistance to malaria.

Isn’t the recessive gene for cystic fibrosis also linked to malaria resistance?

Edit: apparently it might be linked to a resistance to cholera.

Re: Evolutionary gene loss may explain why only humans are prone to heart attack

#15

Post by watertom »

JohnJamesRambo wrote: post #11
watertom wrote: post #10

Linus Pauling figured out almost 30 years ago why humans are prone to heart attacks, and not only did he discover why, he also has a mechanism by which to reverse existing heart disease and prevent heart attacks and strokes. The Pharmaceutical industry ridiculed his solution and tried to discredit his work, claiming that he had become crazy in his old age. Personally I have much more faith in Dr. Pauling than I do in…

I hate to attack your deity but... https://www.quackwatch.org/01QuackeryRelatedTopics/pauling.h... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5000725/ “Overall, current research suggests that vitamin C deficiency is associated with a higher risk of mortality from CVD and that vitamin C may slightly improve endothelial function and lipid profiles in some groups, especially those with low plasma vitamin C levels. How…

Dr. Pauling theory does focus on L-ascorbic acid, but his unified theory relies on L-Lysine as well.

Not one published study that claims to refute Dr. Pauling's unified theory ever used the amount of L-ascorbic acid he recommended, or included L-lysine as part of the study. Dr. Pauling's unified theory has specific guideline amounts, as MG per KG of body weight for both L-ascorbic acid and L-lysine. It would be trivial to actually test Dr. Pauling's theory, but so far everyone has felt the need to alter his recommendations and then test their alteration and then claim victory.

It's easy to knock down a straw man, and even easier to revel in the success.

Re: Evolutionary gene loss may explain why only humans are prone to heart attack

#16

Post by svachalek »

deanstag wrote: post #12
dilawar wrote: post #9

I wonder if a gone lost hundreds of years ago is somehow _responsible_, then why heart attack related death mostly occured in last 50 years?

It could be that they were not diagnosed as heart attacks before that. edit: And also maybe general life style differences regarding availability and richness of food, exercise, shorter life spans etc.

In the 19th century, a heart attack may have been recorded as "old age", "sudden death", "apoplexy", "stomach cramps", "spasms", or a lot of other things. As long there weren't any suspicious circumstances I don't think they usually looked into it that closely.

Re: Evolutionary gene loss may explain why only humans are prone to heart attack

#19

Post by ctack »

watertom wrote: post #10

Linus Pauling figured out almost 30 years ago why humans are prone to heart attacks, and not only did he discover why, he also has a mechanism by which to reverse existing heart disease and prevent heart attacks and strokes. The Pharmaceutical industry ridiculed his solution and tried to discredit his work, claiming that he had become crazy in his old age. Personally I have much more faith in Dr. Pauling than I do in…

Ugh. Matthias Rath has got a lot of blood on his hands. His “vitamins cure AIDS and heart disease” shpiel directly killed people during his “clinical trials” in South Africa. He also influenced and exacerbated AIDS denialism, the denialism which which lead to the deaths of tens of thousands people and is largely responsible for the incumbency of populist and massively corrupt president Jacob Zuma which has seriously set that country back.

Matthias Rath. Just wow. What a savagely ruthless piece of work.

Edited out the profanity at end.

Re: Evolutionary gene loss may explain why only humans are prone to heart attack

#20

Post by arrosenberg »

watertom wrote: post #15
JohnJamesRambo wrote: post #11

Earlier quoted context omitted.

I hate to attack your deity but... https://www.quackwatch.org/01QuackeryRelatedTopics/pauling.h... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5000725/ “Overall, current research suggests that vitamin C deficiency is associated with a higher risk of mortality from CVD and that vitamin C may slightly improve endothelial function and lipid profiles in some groups, especially those with low plasma vitamin C levels. How…

Dr. Pauling theory does focus on L-ascorbic acid, but his unified theory relies on L-Lysine as well. Not one published study that claims to refute Dr. Pauling's unified theory ever used the amount of L-ascorbic acid he recommended, or included L-lysine as part of the study. Dr. Pauling's unified theory has specific guideline amounts, as MG per KG of body weight for both L-ascorbic acid and L-lysine. It would be trivi…

More than one of my Biochemistry professors lamented the fact that Pauling ruined his legacy with the Vitamin C obsession, but there is no evidence it worked.
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