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Scientists discover the chemicals behind the unique Parkinson’s smell

economist.com

11–20 of 68 posts

Re: Scientists discover the chemicals behind the unique Parkinson’s smell

#11

EDITED: She can also smell Alzheimer's, even before a person is about to develop it. https://www.express.co.uk/life-style/health/1107030/dementia...

But her sensitivity to smell means she is unable to enter the cleaning products aisle in supermarkets. To most people, the plastic packaging has no odour; to Joy, it is so intense she starts to retch. Is that even remotely true that people can't smell that aisle? I don't think I have an extraordinary sense of smell and I think of the smell of that aisle as "rank" or something like that.

I think I can smell that aisle, but it's from the detergent, not the plastic.

Re: Scientists discover the chemicals behind the unique Parkinson’s smell

#14
post #9

Smell represents an entirely new approach to medical diagnosis and in the next decade god knows how many tests we'd be able to develop using this approach. I am truly excited!

> Smell represents an entirely new approach to medical diagnosis

It's not new at all. Traditional Chinese medicine has used it for a long time, among others.

Re: Scientists discover the chemicals behind the unique Parkinson’s smell

#16
> perillic aldehyde, hippuric acid, eicosane and octadecanal

It's tantalizing to see the names fixed in print. To make a software dev analogy, it's like finally reproducing a heisenbug and knowing it's very likely you'll find the root cause soon.

Re: Scientists discover the chemicals behind the unique Parkinson’s smell

#18
November 15, 2018 publication:

Discovery of volatile biomarkers of Parkinsons disease from sebum

https://doi.org/10.1101/469726 (free full-text PDF link on site)

From the abstract:

We have serendipitously identified a hyperosmic individual, a Super Smeller that can detect Parkinson's Disease(PD) by odor alone, and our early pilot studies have indicated that the odor was present in the sebum from the skin of PD subjects.

Re: Scientists discover the chemicals behind the unique Parkinson’s smell

#19
post #16

> perillic aldehyde, hippuric acid, eicosane and octadecanal It's tantalizing to see the names fixed in print. To make a software dev analogy, it's like finally reproducing a heisenbug and knowing it's very likely you'll find the root cause soon.

What is a heisenbug?

Re: Scientists discover the chemicals behind the unique Parkinson’s smell

#20
post #16

> perillic aldehyde, hippuric acid, eicosane and octadecanal It's tantalizing to see the names fixed in print. To make a software dev analogy, it's like finally reproducing a heisenbug and knowing it's very likely you'll find the root cause soon.

What is a heisenbug?

A bug that this one customer keeps reporting and no developer in the team can replicate, until it happens one day and it happens constantly, until you try to debug it, because then the bug will never happen again. ️

https://en.m.wikipedia.org/wiki/Heisenbug

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