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New study provides evidence that we need different drugs for men and women

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Re: New study provides evidence that we need different drugs for men and women

#11

Post by jonnybgood »

djsumdog wrote: post #9
mamon wrote: post #6

Are doctors even allowed to ask patients about their gender? That's sensitive private info, right? Also, people are free to choose their own gender and even change their mind about it every other week, so the therapy would need to be adjusted accordingly. /s

I realize this is meant as a joke, but in all seriousness, this does go against some of the absurdist grain of what we're seeing today. No one should be bullied or made fun of for their beliefs, but the idea that biological sex is some type of subjective personal choice is ideological; even religious. Papers like this could seriously face censorship in the future, and it's something we need to address and take seriou…

> No one should be bullied or made fun of for their beliefs, but the idea that biological sex is some type of subjective personal choice is ideological; even religious.

You’re confusing sex with gender.

Re: New study provides evidence that we need different drugs for men and women

#14

Post by dang »

mamon wrote: post #6

Are doctors even allowed to ask patients about their gender? That's sensitive private info, right? Also, people are free to choose their own gender and even change their mind about it every other week, so the therapy would need to be adjusted accordingly. /s

Please don't post flamebait to HN.

https://news.ycombinator.com/newsguidelines.html

Re: New study provides evidence that we need different drugs for men and women

#15

Post by xeeeeeeeeeeenu »

The mechanism of action of analgesic drugs is very simple and well-understood.

Considering the fact that the very same painkillers that humans use are effective on drastically different organisms, such as snails or crustaceans, I find it extremely unlikely that gender plays any significant role in their effectiveness.

To be honest, it feels like this study was politically motivated.

Re: New study provides evidence that we need different drugs for men and women

#16

Post by aura_inquiry »

shard972 wrote: post #13

The article says nothing about how many trans people they had enrolled in the study. I thought we were already past this but no, in 2019 trans individuals are still second class citizens.

I believe explanation is that they simply excluded mentally ill applicants.

Re: New study provides evidence that we need different drugs for men and women

#17

Post by Fellshard »

djsumdog wrote: post #9
mamon wrote: post #6

Are doctors even allowed to ask patients about their gender? That's sensitive private info, right? Also, people are free to choose their own gender and even change their mind about it every other week, so the therapy would need to be adjusted accordingly. /s

I realize this is meant as a joke, but in all seriousness, this does go against some of the absurdist grain of what we're seeing today. No one should be bullied or made fun of for their beliefs, but the idea that biological sex is some type of subjective personal choice is ideological; even religious. Papers like this could seriously face censorship in the future, and it's something we need to address and take seriou…

This, exactly. If a doctor can be essentially disbarred for providing a recommended treatment specific to one's biological sex regardless of the patient's view on their gender, and that demand is made by the patient _to the patient's detriment_, doctors are put in an impossible situation, forsaking their oath in all courses of action.

Re: New study provides evidence that we need different drugs for men and women

#18

Post by Swizec »

tomlock wrote: post #12

I'd ask everyone who came to this article with the assumption that someone would object to or get offended by this finding, to actually observe if anyone does.

Right above you, someone getting offended that there aren’t enough trans people in the study. I thought that was an interesting coincidence.

https://pasteboard.co/I6fhTWy.jpg

Re: New study provides evidence that we need different drugs for men and women

#19

Post by tropdrop »

Some takeaways that underscore the fact that it took the NIH until 2016 to require animal research to feature both male and female animals -

"Women greatly outnumber men among migraine sufferers, and women made up about 85 percent of the participants in the Phase 3 clinical trials of the three anti-CGRP drugs approved by the Food and Drug Administration in 2018. Price wonders if the anti-CGRP drugs aren’t specific to migraines—but to women. His work with mice suggests that the drugs don’t work in males, but block pain in females.

Mogil once emailed a researcher, asking whether a pain drug worked better in men than women. The researcher didn’t know, and couldn’t pursue the question because the data was controlled by the pharmaceutical company. Mogil was left wondering if drugs that looked promising in male-only animal studies might have failed in clinical trials when the results were blended with those in women, depriving men of a viable treatment...

[Meanwhile] medicines that could work best for women wouldn’t make it into the pipeline at all when basic science excluded female animals. Price wonders if unresolved pain among women might have led to their higher levels of chronic pain."

Re: New study provides evidence that we need different drugs for men and women

#20

Post by Red_Tarsius »

shard972 wrote: post #13

The article says nothing about how many trans people they had enrolled in the study. I thought we were already past this but no, in 2019 trans individuals are still second class citizens.

It's already difficult to get enough funding as is, you can't realistically expect the researchers to allocate a meaningful amount of resources to survey 0.6 of the population.
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