As a long-term, transplanted resident of Virginia, however, I’m keenly aware of the statistically small, but non-zero chance of running afoul with a (suspected) brown recluse. In 2014 I spent six days in the hospital after being being bitten on the ankle.
Extensive courses of I.V. antibiotics were used to combat the necrotizing aspects of the venom. Along with a number of different topical anti-bactrials.
Unfortunately, because I did not capture the spider which bit me, it was impossible to definitively point to Loxosceles as the culprit, thus complicating treatment.
Recluse spider bites can be (relatively) painless, initially, and it could have happened while I was out hiking in the woods and stopped for a rest, or earlier, while at my home.