I would love to know how this animation was made. Is there any sort of simulation happening?
The life cycle of HIV in 3D [video]
11–20 of 72 posts
Re: The life cycle of HIV in 3D [video]
#12Absolutely insane how this is actual reality. That millions of people have died from such a small object that seems to have more creativity and complexity than I’ve ever seen.
You might enjoy:
Influenza A (H1N1) – How many bits does it take to kill a human?
https://www.bunniestudios.com/blog/?p=353
Re: The life cycle of HIV in 3D [video]
#13Question. How is that even knowing the lifecycle of HIV at this level of detail, there is not a cure for it?
Re: The life cycle of HIV in 3D [video]
#14Absolutely insane how this is actual reality. That millions of people have died from such a small object that seems to have more creativity and complexity than I’ve ever seen.
You might enjoy: Influenza A (H1N1) – How many bits does it take to kill a human? https://www.bunniestudios.com/blog/?p=353
Thanks for sharing. That’s terrifying. I feel like this should be read by more people.
Re: The life cycle of HIV in 3D [video]
#15Question. How is that even knowing the lifecycle of HIV at this level of detail, there is not a cure for it?
Re: The life cycle of HIV in 3D [video]
#16Question. How is that even knowing the lifecycle of HIV at this level of detail, there is not a cure for it?
One major issue is the fact that reverse transcriptase, which copies the HIV genome inside the cell, is sloppy and makes lots of mistakes. As a consequence, every viral particle produced is a little different. A drug that targets any given HIV protein to disrupt it, will work on most particles, but there’s always some that carry mutations that allow them to escape. The solution is to treat with multiple orthogonal drugs.
However,a second major issue is what’s mentioned in the movie, that the viral genome integrates into the host genome and can lie dormant for years. So even if you kill off every single viral particle, years later new particles can be produced from the dormant genome.
A third major issue is that HIV specifically infects T cells, which are the very immune cells that are supposed to combat infection. This weakens the natural defenses, and also makes it difficult to create a successful vaccine.
Re: The life cycle of HIV in 3D [video]
#17Question. How is that even knowing the lifecycle of HIV at this level of detail, there is not a cure for it?
One of the problems is that HIV stitches it's DNA into the cells DNA. The result is a latent infection reservoir that can last decades.
Re: The life cycle of HIV in 3D [video]
#18Question. How is that even knowing the lifecycle of HIV at this level of detail, there is not a cure for it?
One major issue is the fact that reverse transcriptase, which copies the HIV genome inside the cell, is sloppy and makes lots of mistakes. As a consequence, every viral particle produced is a little different. A drug that targets any given HIV protein to disrupt it, will work on most particles, but there’s always some that carry mutations that allow them to escape. The solution is to treat with multiple orthogonal dr…
I would think that once you kill all infected T-cells, yo got rid of all infection?
Re: The life cycle of HIV in 3D [video]
#19The amazing part for me was that virus "code" automatically finds the unrelated host "code" in what is effectively an equivalent of space travel inside a host body, does copy and paste to insert itself somewhere in host code and everything just works! I can't think of any of our computing models that is capable of doing this and so robust at errors.
Re: The life cycle of HIV in 3D [video]
#20Mindblowing. To think that chance+time produced something like that is staggering.
+reproduction +selection