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Nicotinamide riboside effects on aging similar to caloric restriction

colorado.edu

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Re: Nicotinamide riboside effects on aging similar to caloric restriction

#11

Post by ScottBurson »

isoprophlex wrote: post #3

There is a very annoying, pervasive typo in the article and in the title on hn. It's 'nicotinamide'. In chemistry, an omide isn't really a thing. Edit: and I'll add another sour note... I noticed this now, but how often did i read a piece of journalism outside my area of expertise with equally lazy mistakes, without noticing them?

One of my pet peeves is journalists who don't understand what a watt is. I frequently see statements like "The plant will produce 50MW, enough to power 40,000 homes for a year."

Re: Nicotinamide riboside effects on aging similar to caloric restriction

#12

Post by lvs »

OK, the headline and press release basically have nothing to do with the underlying paper.

The paper itself is a small sample size (24) trial that looks at tolerance. There are no statistically significant physiological effects of dosing with NR in the paper. You see a small increase in the levels of various metabolites that you would expect to see increase after dosing. They only look at cardiovascular effects, and the results are inconclusive at best.

University press offices are doing nobody any favors with this kind of thing. It has to stop.

https://www.nature.com/articles/s41467-018-03421-7.pdf

Re: Nicotinamide riboside effects on aging similar to caloric restriction

#13

Post by jimrandomh »

blunte wrote: post #2

As a min/max gamer, I have to ask: do these stack? (nicotinamide riboside AND caloric restriction) But I do disagree with the article that caloric restriction is impractical or dangerous - at least for "rich" western societies that already consume 50%+ more than their healthier eastern counterparts.

> consume 50%+ more than their healthier eastern counterparts

That's not true. https://en.wikipedia.org/wiki/List_of_countries_by_food_ener...

Re: Nicotinamide riboside effects on aging similar to caloric restriction

#15

Post by mkempe »

epmaybe wrote: post #4

"We are not able to make any definitive claims that this compound is safe..." Is this quote taken out of context? Because I thought the first step of any sort of human trial of a drug is to determine its safety. Intuitively I can't see how NR would be any different safety-wise than niacin (vitamin b3), but more clarification would be nice. Anyone who has read the paper willing to chime in?

What they mean is that they are not allowed by the FDA to make any such claims.

Re: Nicotinamide riboside effects on aging similar to caloric restriction

#16

Post by blunte »

jimrandomh wrote: post #13
blunte wrote: post #2

As a min/max gamer, I have to ask: do these stack? (nicotinamide riboside AND caloric restriction) But I do disagree with the article that caloric restriction is impractical or dangerous - at least for "rich" western societies that already consume 50%+ more than their healthier eastern counterparts.

> consume 50%+ more than their healthier eastern counterparts That's not true. https://en.wikipedia.org/wiki/List_of_countries_by_food_ener...

I'm sorry, 50% is higher than actual. But still, is 3750 for US vs 2550 for Indonesia (about the same population), or 2800 for Japan, or 2990 for China any indication of a significant caloric intake difference?

Further, the type and quality of the food is likely much lower for the US group consider just the relative carbonated, sugared beverage.

Re: Nicotinamide riboside effects on aging similar to caloric restriction

#17

Post by Greenisus »

blunte wrote: post #2

As a min/max gamer, I have to ask: do these stack? (nicotinamide riboside AND caloric restriction) But I do disagree with the article that caloric restriction is impractical or dangerous - at least for "rich" western societies that already consume 50%+ more than their healthier eastern counterparts.

I would expect them not to stack and that you're probably better off just sticking with fasting instead of seeking a shortcut.

Re: Nicotinamide riboside effects on aging similar to caloric restriction

#18

Post by isoprophlex »

withoutclass wrote: post #7
oakwhiz wrote: post #5

Earlier quoted context omitted.

>how often did i read a piece of journalism outside my area of expertise with equally lazy mistakes, without noticing them? This is often referred to as the "Gell-Mann Amnesia Effect": "Briefly stated, the Gell-Mann Amnesia effect works as follows. You open the newspaper to an article on some subject you know well. In Murray’s case, physics. In mine, show business. You read the article and see the journalist has abso…

Thanks for this, a most excellent TIL.

Yeah thanks a thousand. This is exactly what I mean. It's kind of grating, only today I realise that "I turn the page, and forget what I know."

Re: Nicotinamide riboside effects on aging similar to caloric restriction

#19

Post by SCAQTony »

epmaybe wrote: post #4

"We are not able to make any definitive claims that this compound is safe..." Is this quote taken out of context? Because I thought the first step of any sort of human trial of a drug is to determine its safety. Intuitively I can't see how NR would be any different safety-wise than niacin (vitamin b3), but more clarification would be nice. Anyone who has read the paper willing to chime in?

Well, it is in cow milk: https://www.ncbi.nlm.nih.gov/pubmed/27052539

Re: Nicotinamide riboside effects on aging similar to caloric restriction

#20

Post by deegles »

Does anyone know where to get it in bulk form? The commercial stuff I've seen seems way overpriced.

Also, I'm happy for the disclosure but be wary of potential bias...

> The study was partially funded by grants from the National Institutes of Health and the American Federation for Aging Research. ChromaDex, the maker of NIAGEN provided supplements and some financial support.

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