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Ibuprofen alters human testicular physiology including testosterone production

pnas.org

11–20 of 67 posts

Re: Ibuprofen alters human testicular physiology including testosterone production

#11
post #9

While the results do matter, this is probably being blown out of proportion > One group of subjects received ibuprofen, 2 × 600 mg/d, (Ibumetin; Nycomed Denmark Aps) for a period of 6 wk Yeah, that's a lot of Ibuprofen for a long time

I've known plenty of people who do 400mg 2-3x/day for weeks/months.

Military?

Re: Ibuprofen alters human testicular physiology including testosterone production

#12

While the results do matter, this is probably being blown out of proportion > One group of subjects received ibuprofen, 2 × 600 mg/d, (Ibumetin; Nycomed Denmark Aps) for a period of 6 wk Yeah, that's a lot of Ibuprofen for a long time

Have you seen how some people gobble this stuff? I've felt compelled to say to more than one person: probably shouldn't take that much ...

Sometimes pain management is a balancing act between dangerous side effects and misery that makes it hard to want to keep living. Chronic pain isn't really something a third party can make decisions about; it may be that ibuprofen isn't the right choice, but lots of other choices (opiates, for instance) may have even more negative effects (like addiction and risk of deadly overdose).

Of course, there are folks who take over-the-counter meds as though it is safe at any dose and frequency. That might warrant a nudge toward reading the label about safe dosage, or a mention of a recent study on the subject.

Re: Ibuprofen alters human testicular physiology including testosterone production

#13

While the results do matter, this is probably being blown out of proportion > One group of subjects received ibuprofen, 2 × 600 mg/d, (Ibumetin; Nycomed Denmark Aps) for a period of 6 wk Yeah, that's a lot of Ibuprofen for a long time

Nope, that is literally the dosage mentioned in leaflet inside my box of pills: 2x200mg, up to 3 times a day, do not exceed 6 weeks.

Re: Ibuprofen alters human testicular physiology including testosterone production

#14

While the results do matter, this is probably being blown out of proportion > One group of subjects received ibuprofen, 2 × 600 mg/d, (Ibumetin; Nycomed Denmark Aps) for a period of 6 wk Yeah, that's a lot of Ibuprofen for a long time

Nope, that is literally the dosage mentioned in leaflet inside my box of pills: 2x200mg, up to 3 times a day, do not exceed 6 weeks.

I'm not saying it's an overdose (and their tests of renal and hepatic function corroborate that)

But it's not a dose people will commonly take in their "day to day" activities and ideally not something that is done without medical supervision

Re: Ibuprofen alters human testicular physiology including testosterone production

#15
post #10
post #7

Earlier quoted context omitted.

Blame the journal. Scientists are generally pretty busy. Writing a (life sciences) paper is an incredible amount of work usually done in a short period of time. Preparing raw data and explaining what everything means is quite involved. If they don't have to do something they won't. The journal should mandate data access, then it will get done. This is crucial for human experiments, if only because the authors can los…

As far as I know this is slowly changing. According to scientists I've met (life science fields) there is an ongoing trend towards demanding raw data and even the code used to analyze it. Not every journal everywhere yet of course, but the consensus seemed to be that in 5 to 10 years it would become the new norm. Which might cause quite the disruption. Having seen quite the amounts of code written by PHD students I'm…

I think this is a good trend. The opening of raw data AND the code used to analyse it will aid in others being able to find errors sooner.

Re: Ibuprofen alters human testicular physiology including testosterone production

#16

While the results do matter, this is probably being blown out of proportion > One group of subjects received ibuprofen, 2 × 600 mg/d, (Ibumetin; Nycomed Denmark Aps) for a period of 6 wk Yeah, that's a lot of Ibuprofen for a long time

I've been prescribed that sort of dosage to deal with inflammatory issues. From limited personal experience, larger does are not about pain relief, but bringing inflammation (eg bursitis) under control.

Re: Ibuprofen alters human testicular physiology including testosterone production

#17

Earlier quoted context omitted.

Have you seen how some people gobble this stuff? I've felt compelled to say to more than one person: probably shouldn't take that much ...

Sometimes pain management is a balancing act between dangerous side effects and misery that makes it hard to want to keep living. Chronic pain isn't really something a third party can make decisions about; it may be that ibuprofen isn't the right choice, but lots of other choices (opiates, for instance) may have even more negative effects (like addiction and risk of deadly overdose). Of course, there are folks who ta…

Exactly this. I have a chronic wrist injury from a previous job. Physiotherapy hasn't really helped, and the only thing that does help when I have a bad day is naproxen (another NSAID in the same class as ibuprofen). I feel guilty taking it in the dose I do (1000mg/day) but it's the only thing that makes life bearable and makes me functional.

Re: Ibuprofen alters human testicular physiology including testosterone production

#18
post #11
post #9

Earlier quoted context omitted.

I've known plenty of people who do 400mg 2-3x/day for weeks/months.

Military?

Collegiate and professional athletes easily would do this. (I've personally done it, hell.)

Construction workers, manual laborers, etc.

Re: Ibuprofen alters human testicular physiology including testosterone production

#19

Earlier quoted context omitted.

Nope, that is literally the dosage mentioned in leaflet inside my box of pills: 2x200mg, up to 3 times a day, do not exceed 6 weeks.

I'm not saying it's an overdose (and their tests of renal and hepatic function corroborate that) But it's not a dose people will commonly take in their "day to day" activities and ideally not something that is done without medical supervision

It's one of the features of Ibuprofen that you can take it at those levels without killing yourself. Most people don't, but some people do - sometimes because doctors tell them to.

This makes it different to Paracetamol, where you only have to double or triple the standard dose to cause temporary liver damage, and increasing it only slightly further puts you in danger of death.

Re: Ibuprofen alters human testicular physiology including testosterone production

#20
post #2

I've been paying attention to the lowering fertility rate across the world. My instinct, until now, was that it was because of fire retardant chemicals found in furniture that act as an endocrine disruptor. It didn't totally fit though so I felt like there was something else that was a major contributor. Ibuprofen being a cause of lower sperm counts could be the missing piece of the puzzle. It's also a big deal becau…

Are there any good numbers on the fertility among people who actually WANT to conceive, rather than the raw total population rates (which is affected by people who don't want kids - prevented through birth control and abortions)
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