While the results do matter, this is probably being blown out of proportion > One group of subjects received ibuprofen, 2 × 600 mg/d, (Ibumetin; Nycomed Denmark Aps) for a period of 6 wk Yeah, that's a lot of Ibuprofen for a long time
I've known plenty of people who do 400mg 2-3x/day for weeks/months.
Ibuprofen alters human testicular physiology including testosterone production
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Re: Ibuprofen alters human testicular physiology including testosterone production
#12While the results do matter, this is probably being blown out of proportion > One group of subjects received ibuprofen, 2 × 600 mg/d, (Ibumetin; Nycomed Denmark Aps) for a period of 6 wk Yeah, that's a lot of Ibuprofen for a long time
Have you seen how some people gobble this stuff? I've felt compelled to say to more than one person: probably shouldn't take that much ...
Of course, there are folks who take over-the-counter meds as though it is safe at any dose and frequency. That might warrant a nudge toward reading the label about safe dosage, or a mention of a recent study on the subject.
Re: Ibuprofen alters human testicular physiology including testosterone production
#13While the results do matter, this is probably being blown out of proportion > One group of subjects received ibuprofen, 2 × 600 mg/d, (Ibumetin; Nycomed Denmark Aps) for a period of 6 wk Yeah, that's a lot of Ibuprofen for a long time
Re: Ibuprofen alters human testicular physiology including testosterone production
#14While the results do matter, this is probably being blown out of proportion > One group of subjects received ibuprofen, 2 × 600 mg/d, (Ibumetin; Nycomed Denmark Aps) for a period of 6 wk Yeah, that's a lot of Ibuprofen for a long time
Nope, that is literally the dosage mentioned in leaflet inside my box of pills: 2x200mg, up to 3 times a day, do not exceed 6 weeks.
But it's not a dose people will commonly take in their "day to day" activities and ideally not something that is done without medical supervision
Re: Ibuprofen alters human testicular physiology including testosterone production
#15Earlier quoted context omitted.
Blame the journal. Scientists are generally pretty busy. Writing a (life sciences) paper is an incredible amount of work usually done in a short period of time. Preparing raw data and explaining what everything means is quite involved. If they don't have to do something they won't. The journal should mandate data access, then it will get done. This is crucial for human experiments, if only because the authors can los…
As far as I know this is slowly changing. According to scientists I've met (life science fields) there is an ongoing trend towards demanding raw data and even the code used to analyze it. Not every journal everywhere yet of course, but the consensus seemed to be that in 5 to 10 years it would become the new norm. Which might cause quite the disruption. Having seen quite the amounts of code written by PHD students I'm…
Re: Ibuprofen alters human testicular physiology including testosterone production
#16While the results do matter, this is probably being blown out of proportion > One group of subjects received ibuprofen, 2 × 600 mg/d, (Ibumetin; Nycomed Denmark Aps) for a period of 6 wk Yeah, that's a lot of Ibuprofen for a long time
Re: Ibuprofen alters human testicular physiology including testosterone production
#17Earlier quoted context omitted.
Have you seen how some people gobble this stuff? I've felt compelled to say to more than one person: probably shouldn't take that much ...
Sometimes pain management is a balancing act between dangerous side effects and misery that makes it hard to want to keep living. Chronic pain isn't really something a third party can make decisions about; it may be that ibuprofen isn't the right choice, but lots of other choices (opiates, for instance) may have even more negative effects (like addiction and risk of deadly overdose). Of course, there are folks who ta…
Re: Ibuprofen alters human testicular physiology including testosterone production
#18Re: Ibuprofen alters human testicular physiology including testosterone production
#19Earlier quoted context omitted.
Nope, that is literally the dosage mentioned in leaflet inside my box of pills: 2x200mg, up to 3 times a day, do not exceed 6 weeks.
I'm not saying it's an overdose (and their tests of renal and hepatic function corroborate that) But it's not a dose people will commonly take in their "day to day" activities and ideally not something that is done without medical supervision
This makes it different to Paracetamol, where you only have to double or triple the standard dose to cause temporary liver damage, and increasing it only slightly further puts you in danger of death.
Re: Ibuprofen alters human testicular physiology including testosterone production
#20I've been paying attention to the lowering fertility rate across the world. My instinct, until now, was that it was because of fire retardant chemicals found in furniture that act as an endocrine disruptor. It didn't totally fit though so I felt like there was something else that was a major contributor. Ibuprofen being a cause of lower sperm counts could be the missing piece of the puzzle. It's also a big deal becau…