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'Ideal biomarker' detects Alzheimer's disease before the onset of symptoms

eurekalert.org

11–20 of 20 posts

Re: 'Ideal biomarker' detects Alzheimer's disease before the onset of symptoms

#11
post #2

The article claims this test will promptly be used clinically. Diagnosing Alzheimer’s while there is no cure or treatment available is useless. If used, the test unnecessarily burdens patients sooner. I can see the importance of this test in helping to find the root cause of Alzheimer’s, but I can’t see why this test would be used clinically while we can’t do anything about Alzheimer’s.

There's nothing curative, but there's a fair bit of palliative care drugs, esp. for early stage, at this point. Getting on them a little early might mean another year or two of independence which is no small thing.

Re: 'Ideal biomarker' detects Alzheimer's disease before the onset of symptoms

#12
post #9

This sounds almost too good to be true. It's published in a lower impact journal so I'm wondering if the sample size was very small. Also, how did they confirm the 'topography of the pathophysiology' (where the disease is) without taking people's scalps off?

Looks like n=20 from skimming. MEG and MRI scans were used. http://onlinelibrary.wiley.com/doi/10.1002/hbm.23724/epdf

Yep. Far too early to get excited.

Re: 'Ideal biomarker' detects Alzheimer's disease before the onset of symptoms

#13
post #2

The article claims this test will promptly be used clinically. Diagnosing Alzheimer’s while there is no cure or treatment available is useless. If used, the test unnecessarily burdens patients sooner. I can see the importance of this test in helping to find the root cause of Alzheimer’s, but I can’t see why this test would be used clinically while we can’t do anything about Alzheimer’s.

It might let you plan your suicide while you are still able to.

Re: 'Ideal biomarker' detects Alzheimer's disease before the onset of symptoms

#14
post #2

The article claims this test will promptly be used clinically. Diagnosing Alzheimer’s while there is no cure or treatment available is useless. If used, the test unnecessarily burdens patients sooner. I can see the importance of this test in helping to find the root cause of Alzheimer’s, but I can’t see why this test would be used clinically while we can’t do anything about Alzheimer’s.

I'd definitely like to know if my future includes Alzheimer's. At the very least, I'd stop saving for retirement. You say we can't do anything about the disease, but as an individual, I can certainly decide how far I want to let the disease progress.

Re: 'Ideal biomarker' detects Alzheimer's disease before the onset of symptoms

#15
post #2

The article claims this test will promptly be used clinically. Diagnosing Alzheimer’s while there is no cure or treatment available is useless. If used, the test unnecessarily burdens patients sooner. I can see the importance of this test in helping to find the root cause of Alzheimer’s, but I can’t see why this test would be used clinically while we can’t do anything about Alzheimer’s.

I'd definitely like to know if my future includes Alzheimer's. At the very least, I'd stop saving for retirement. You say we can't do anything about the disease, but as an individual, I can certainly decide how far I want to let the disease progress.

It seems unwise to assume that we won’t find a cure or treatment in the next n decades.

Re: 'Ideal biomarker' detects Alzheimer's disease before the onset of symptoms

#16
post #2

The article claims this test will promptly be used clinically. Diagnosing Alzheimer’s while there is no cure or treatment available is useless. If used, the test unnecessarily burdens patients sooner. I can see the importance of this test in helping to find the root cause of Alzheimer’s, but I can’t see why this test would be used clinically while we can’t do anything about Alzheimer’s.

I wish I could upvote your comment several times over.

One of the commonest fallacies that we carry over from everyday life, over to chronic disease is that early detection followed by intervention will reduce the burden/discomfort/work in the future. We are probably wired for this fallacy, for example in the prehistoric era: detect an impending attack by an invading enemy would have resulted in better survival.

Some non-main stream cancer practitioners postulate that the only reason cancer survival rates seem to have improved over the years is because of earlier detection. A cancer survivor is broadly defined as someone who lives 5 years after detection of the cancer. So in the distance past when detection methods were relatively primitive cancer was detected at the later stages and the patient died quickly there after. Now they live longer after they have been detected because it was detected relatively earlier. The better survival rate is attributed to the treatment regiment, which is not the case. It is just that the window of time between detection of cancer and death of patient has increased.

Anyways, none of this is news to people are understand human nature, there is quite a bit of 'superstition' even in science and medicine.

Re: 'Ideal biomarker' detects Alzheimer's disease before the onset of symptoms

#17
post #15

Earlier quoted context omitted.

I'd definitely like to know if my future includes Alzheimer's. At the very least, I'd stop saving for retirement. You say we can't do anything about the disease, but as an individual, I can certainly decide how far I want to let the disease progress.

It seems unwise to assume that we won’t find a cure or treatment in the next n decades.

I wouldn't say it's unwise, but there's definitely a decision to be made.

If I decide to let the disease progress to the point where I don't know my family members and am acting violently, how likely is it that a cure is going to be found that can reverse that damage? I don't think it's very likely and so I would probably choose to die before that point.

Re: 'Ideal biomarker' detects Alzheimer's disease before the onset of symptoms

#18
post #2

The article claims this test will promptly be used clinically. Diagnosing Alzheimer’s while there is no cure or treatment available is useless. If used, the test unnecessarily burdens patients sooner. I can see the importance of this test in helping to find the root cause of Alzheimer’s, but I can’t see why this test would be used clinically while we can’t do anything about Alzheimer’s.

The same could be said for the Huntington's Disease test, which has been around for a long time.

It's difficult for potential sufferers of Huntington's Disease to decide whether they want the test. Some do and others do not, but most potential Huntington's Disease sufferers are happy that the test is available.

Re: 'Ideal biomarker' detects Alzheimer's disease before the onset of symptoms

#19
post #2

The article claims this test will promptly be used clinically. Diagnosing Alzheimer’s while there is no cure or treatment available is useless. If used, the test unnecessarily burdens patients sooner. I can see the importance of this test in helping to find the root cause of Alzheimer’s, but I can’t see why this test would be used clinically while we can’t do anything about Alzheimer’s.

I'd definitely like to know if my future includes Alzheimer's. At the very least, I'd stop saving for retirement. You say we can't do anything about the disease, but as an individual, I can certainly decide how far I want to let the disease progress.

Given that a number of countries/US states have euthanasia laws on the books, it is definitely an actionable diagnosis at this point.

Re: 'Ideal biomarker' detects Alzheimer's disease before the onset of symptoms

#20
post #15

Earlier quoted context omitted.

It seems unwise to assume that we won’t find a cure or treatment in the next n decades.

I wouldn't say it's unwise, but there's definitely a decision to be made. If I decide to let the disease progress to the point where I don't know my family members and am acting violently, how likely is it that a cure is going to be found that can reverse that damage? I don't think it's very likely and so I would probably choose to die before that point.

Yes, but it doesn’t make sense to avoid saving for retirement.
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