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Evidence of the body’s waste system in the human brain

nih.gov

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Re: Evidence of the body’s waste system in the human brain

#12
post #4
post #2

Interesting stuff, though I could have sworn I'd seen something similar before, to do with the waste draining being one of the reasons we need sleep (i.e. the body needs time to drain the accumulated waste products). Anecdotally, whenever I've had that droopy-eyelids nodding off sensation, when it passes it has always felt like the tiredness is literally draining from my brain.

> being one of the reasons we need sleep Jellyfish have no brain, but also sleep. So that can't be the reason. (It might happen then anyway, but it's not the fundamental reason.)

The quote says "one of the reasons". You replied "can't be the reason". There's a fundamental disconnect there: the person you're replying to didn't say that there was any fundamental reason, or that they were describing it.

Re: Evidence of the body’s waste system in the human brain

#13
post #9
post #4

Earlier quoted context omitted.

> being one of the reasons we need sleep Jellyfish have no brain, but also sleep. So that can't be the reason. (It might happen then anyway, but it's not the fundamental reason.)

You guys keep saying that silly myth. They don't have a BRAIN but they have nervous system. A nervous system creates waste and that waste needs to be reclaimed. What's a brain? An exotic collection of neurons... that create waste. http://neurodojo.blogspot.com/2009/05/jellyfish-nervous-syst... >Instead, jellyfish have a ring nervous system, located along the margin of the bell. There is definitely a concentration of…

It could also be that they don't sleep in the sense of humans.

Re: Evidence of the body’s waste system in the human brain

#14
post #4
post #2

Interesting stuff, though I could have sworn I'd seen something similar before, to do with the waste draining being one of the reasons we need sleep (i.e. the body needs time to drain the accumulated waste products). Anecdotally, whenever I've had that droopy-eyelids nodding off sensation, when it passes it has always felt like the tiredness is literally draining from my brain.

> being one of the reasons we need sleep Jellyfish have no brain, but also sleep. So that can't be the reason. (It might happen then anyway, but it's not the fundamental reason.)

Jellyfish have 5600 neurons though.

Re: Evidence of the body’s waste system in the human brain

#15
post #4
post #2

Interesting stuff, though I could have sworn I'd seen something similar before, to do with the waste draining being one of the reasons we need sleep (i.e. the body needs time to drain the accumulated waste products). Anecdotally, whenever I've had that droopy-eyelids nodding off sensation, when it passes it has always felt like the tiredness is literally draining from my brain.

> being one of the reasons we need sleep Jellyfish have no brain, but also sleep. So that can't be the reason. (It might happen then anyway, but it's not the fundamental reason.)

Although I appreciate this kind of reasoning in general, I think it can be misleading when applied to animal behavior.

What prevents one of the reasons we sleep to be absent from the set of reasons jellyfish sleep?

Also, wouldn't it be surprising if a behavior as complex as sleeping had only one reason, or if the main reason today would be anything like the main reason back in the days were the common ancestor between us and jellyfish lived? And so, shouldn't we expect that we sleep for different reasons?

Re: Evidence of the body’s waste system in the human brain

#17
At first I was incredulous that they would make this claim, since it makes it appear they either failed to follow the literature enough to notice other researchers made the remarkable discovery of this system three years ago, or are trying history revisionism to claim that discovery as their own. But I guess the operative word here is "human". The original research actually gets a small mention in the text body.

Another case of a small but valuable increment of research and nauseating treatment of the same by the spin department I guess.

Re: Evidence of the body’s waste system in the human brain

#18
post #14
post #4

Earlier quoted context omitted.

> being one of the reasons we need sleep Jellyfish have no brain, but also sleep. So that can't be the reason. (It might happen then anyway, but it's not the fundamental reason.)

Jellyfish have 5600 neurons though.

5600 neurons ought be enough for any species.

--- Bill Gates 1982mya

Re: Evidence of the body’s waste system in the human brain

#20
post #19

Can this mean that if one has a lot of stress, then its brain makes a lot of waste which pollute the lymph and thus affects the immune system ? ('cos it's well known that stressed people get sick quicker)

Stress is a factor of hormones and metabolic factors. Brain has constant metabolic consumption whether awake or asleep. Endocrine functions of brain are carried out by release of hormones directly into portal (venous) systems.

Intracellular adenosine which builds up over the course of waking day may be uptaken by brain lymphatics but would play a small part if they are inside the dura as this states. In fact, given clearance rate that is suggested from the article by way of position and size, they likely contribute very minimally to any clearance function if at all(unless further discoveries show intra brain lymphatics)

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