Ok, so QUIC or some other common layer 4/4+5 'Modern TCP over UDP for network compatibility' solution. Lets just throw away the concept of 'addresses' for authentication and actually use a cryptographic authentication identifier of somekind, combined with some mux iteration ID.
Drop the idea of ports too. Every program gets its own IP Mentioning ideas like that at work get queer looks about how it'd be impossible to configure a firewall at that point But keep going further. End up with 128 bit CPU where every byte is IP addressable. Necessary security to block random outsiders from reading your memory, but capable of potentially running various parts remotely transparently
This is already a thing: https://en.wikipedia.org/wiki/Remote_direct_memory_access