The challenge in linking air pollution to age-related disease and mortality risk lies in the confounding correlation with wealth. There are plausible physical mechanisms involving, for example, increased levels of inflammation resulting from high levels of particulate air pollution, but regions with lower levels of air pollution tend to have much wealthier populations, and it is well known that wealth correlates with…
The causal reason is likely the fine particulate matter getting "stuck" in lung tissue and our bodies unable to remove the particles causing accumulative issues on lung function [3].
[1] http://www.nejm.org/doi/full/10.1056/nejmsa0805646
[2] http://circ.ahajournals.org/content/109/1/71.full
[3] http://www.tandfonline.com/doi/pdf/10.1080/10473289.2006.104...