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Not at work, but I use either ES6 or Typescript personally. "All of the syntactic sugar stuff changes the look and feel of the language too much for my tastes." I think it brings it into line with how the language is being used in production these days. Modules, generators etc make the language more beautiful, powerful and easier to maintain.
Not a JS developer, but most of my friends who are have been transitioning to Typescript. The road is bumpy, but they say once you get some syntax stuff down, you're good.