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Why Preventing Cancer Is Not the Priority in Drug Development

nytimes.com

11–20 of 60 posts

Re: Why Preventing Cancer Is Not the Priority in Drug Development

#11

"There’s more money to be made investing in drugs that will extend cancer patients’ lives by a few months than in drugs that would prevent cancer in the first place. That’s one of the findings from the work of Heidi Williams, an M.I.T. economics professor and recent MacArthur Foundation “genius” grant winner, who studied the problem along with Eric Budish, a University of Chicago economics professor, and Ben Roin, as…

There is an enormous amount of money in a cure, mitigation is mere tactical profit that you take when there is no obvious cure. The thing to remember is that, at least in the US biotech market, there are a large number of companies competing for those profits. Patients benefit immensely from mitigation research -- look at HIV. A lot of mitigation therapies were originally "cures" that did not work as well as hoped.

At any point in time, patients have the choice across the spectrum of mitigations or cures. Cures are more difficult to produce but if they are available patients will choose them every time. Companies that produce mitigating medicine are counting on their ability to recoup investment before a cure materializes at some point in the future. If a cure becomes available, the value of their mitigation research goes to zero. Biomedical companies make bets that, if a disease looks particularly difficult to cure, mitigation will retain its value long enough to return a profit as a product.

Most biomedical research companies are looking for cures because it allows them to do an end run around their competitors and grab most of the profits. Every biomedical company wants a cure because it completely displaces competitive mitigation strategies and therefore allows them to collect virtually all of the profits. Mitigation is the fallback position when cures fail. But biomedical research is looking for the cure that will give the a naturally monopoly position by default.

Re: Why Preventing Cancer Is Not the Priority in Drug Development

#13

"There’s more money to be made investing in drugs that will extend cancer patients’ lives by a few months than in drugs that would prevent cancer in the first place. That’s one of the findings from the work of Heidi Williams, an M.I.T. economics professor and recent MacArthur Foundation “genius” grant winner, who studied the problem along with Eric Budish, a University of Chicago economics professor, and Ben Roin, as…

If there's no money in a cure, how are the new hepatitis-c cures being sold for tens of thousands of dollars?

Re: Why Preventing Cancer Is Not the Priority in Drug Development

#14
post #13

"There’s more money to be made investing in drugs that will extend cancer patients’ lives by a few months than in drugs that would prevent cancer in the first place. That’s one of the findings from the work of Heidi Williams, an M.I.T. economics professor and recent MacArthur Foundation “genius” grant winner, who studied the problem along with Eric Budish, a University of Chicago economics professor, and Ben Roin, as…

If there's no money in a cure, how are the new hepatitis-c cures being sold for tens of thousands of dollars?

Very controversially.

Re: Why Preventing Cancer Is Not the Priority in Drug Development

#15
post #8

Earlier quoted context omitted.

What about vaccines? Those are quite easy to make, and are made using existing disease-causing viruses. We know the mechanism, it applies to the whole population, and it's relatively simple and cheap to produce. The logistics are not the same with cancer preventing drugs at all.

Considering that there are no wide spread generic cancer prevention drugs how would you know?

We already know that cancer is not caused by a virus (at least in the general case), so it can't be fixed in the same way as vaccines.

And we've already been looking for cancer drugs for more than half a century to know that the logistics compared to vaccines are different. Let's put it this way: if they knew of a method to make cancer prevention drugs as easy and effective as vaccines, they'd have made them.

Re: Why Preventing Cancer Is Not the Priority in Drug Development

#16

"There’s more money to be made investing in drugs that will extend cancer patients’ lives by a few months than in drugs that would prevent cancer in the first place. That’s one of the findings from the work of Heidi Williams, an M.I.T. economics professor and recent MacArthur Foundation “genius” grant winner, who studied the problem along with Eric Budish, a University of Chicago economics professor, and Ben Roin, as…

> there's no money in a cure

I hope no one actually believes that, because it's really quite a stupid thing to say.

There are TONS of industries that rely on selling things just once to consumers, and yet they have a huge market. How often do you buy a new toilet for example? Yet there are tons of models with lots of competition.

There's plenty of money in a cure.

Re: Why Preventing Cancer Is Not the Priority in Drug Development

#17
post #15

Earlier quoted context omitted.

Considering that there are no wide spread generic cancer prevention drugs how would you know?

We already know that cancer is not caused by a virus (at least in the general case), so it can't be fixed in the same way as vaccines. And we've already been looking for cancer drugs for more than half a century to know that the logistics compared to vaccines are different. Let's put it this way: if they knew of a method to make cancer prevention drugs as easy and effective as vaccines, they'd have made them.

Nonsense there are multiple types of vaccines toxiod vaccines for example vaccinate you against toxic compounds such as snake bites. There is quite a bit of research into regressive therapeutic and preventative vaccines against cancer currently. A vaccine is a process which teaches your immune system to combat a certain condition whether it's caused by a bacteria, parasite, a virus or a toxin it doesn't matter. If you can teach your own immune system to combat cancer by either teaching it to attack certain markers, or by disabling the "stealth" mechanisms which many types of cancer use to fly under it's radar you've effectively created a vaccine.

Also vaccination is one of the most logistically complicated processes in medicine they are extremely short lived require very precise refrigeration and proper administration is considerably more critical than most cancer treatments, 80-90% of the cost of vaccination programs in developed and developing countries alike go into logistics. For cancer treatments even the experimental highly specialized ones it's completely the opposite, and run of the mill treatments like chemotherapy are easily administered by medical technicians under almost any circumstances.

Re: Why Preventing Cancer Is Not the Priority in Drug Development

#18
post #8

Earlier quoted context omitted.

What about vaccines? Those are quite easy to make, and are made using existing disease-causing viruses. We know the mechanism, it applies to the whole population, and it's relatively simple and cheap to produce. The logistics are not the same with cancer preventing drugs at all.

Considering that there are no wide spread generic cancer prevention drugs how would you know?

"Various strains of HPV, which spread through sexual contact, cause most cases of cervical cancer. Two cervical cancer vaccines have Food and Drug Administration (FDA) approval in the U.S. — Gardasil, for girls and boys, and Cervarix, for girls only."

  http://www.mayoclinic.org/healthy-lifestyle/sexual-health/in-depth/cervical-cancer-vaccine/art-20047292

Re: Why Preventing Cancer Is Not the Priority in Drug Development

#19

Earlier quoted context omitted.

Considering that there are no wide spread generic cancer prevention drugs how would you know?

"Various strains of HPV, which spread through sexual contact, cause most cases of cervical cancer. Two cervical cancer vaccines have Food and Drug Administration (FDA) approval in the U.S. — Gardasil, for girls and boys, and Cervarix, for girls only." http://www.mayoclinic.org/healthy-lifestyle/sexual-health/in-depth/cervical-cancer-vaccine/art-20047292

Those aren't vaccines against cancer, those are vaccines against the papilloma virus. Vaccines against HPV are quite commonly administered in Europe, Asia and many middle eastern countries but it's not a wide anti cancer vaccine.

And if it was you do realize that you are only proving my point right?

Re: Why Preventing Cancer Is Not the Priority in Drug Development

#20
post #7

A drug to treat cancer only has to be taken by people diagnosed with that cancer, for as long as they're diagnosed with it. A drug to prevent cancer has to be taken by everyone at risk for the cancer (which might be the entire population), for as long as they're at risk (likely decades). Hence, a treatment drug can be expensive and can have some nasty side-effects, while a prevention drug would have to be cheap with…

Yep. This is basically the same problem we have with Alzheimer's - the people you need to treat are healthy people. The FDA just won’t let you test anything with any danger in healthy people. Since all new treatments inherently have risk it is basically impossible to give a new drug or treatment to healthy people.

Even giving something like metafomin [1] where we have decades of knowledge is in practice impossible to give to healthy people. No new treatment stands a chance.

1. https://en.wikipedia.org/wiki/Metformin

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