Europe votes for clinical trial transparency
alltrials.net
Europe votes for clinical trial transparency
1–10 of 46 posts
Re: Europe votes for clinical trial transparency
#2This is great news - no more pharmaceutical profit projects getting pushed to the forefront, only to discover a few years later that the adverse affects were buried in 'company proprietary confidental' reports .. makes it safer to live in Europe!
Re: Europe votes for clinical trial transparency
#3Both "Bad Pharma" and "Bad Science" are excellent books - strongly recommended:
http://en.wikipedia.org/wiki/Bad_Pharma
http://en.wikipedia.org/wiki/Bad_Science_%28book%29
I wonder if you can get "I am a Nutritionist!" T-shirts?
[Edit: Thanks for pointing out the T-Shirt pretty much does exist].
Re: Europe votes for clinical trial transparency
#4> • Require that a summary understandable to a lay person of what was found in the trial is published on the register.
Good luck with that. Explaining complex cellular mechanisms to a lay person without any scientific nor statistical background is a very difficult task. When you consider modern medicine, you need basic knowledge in genetics, biochemistry, biology, proteins, drug formulation, pharmacology, pharmadynamics, toxicity, clinical studies design, to have a proper understanding of what a study means. We're not talking about aspirin class of medicines anymore, and more and more drugs are now in the class of large molecules.
Re: Europe votes for clinical trial transparency
#5Getting all the information from all clinical trials will probably spur some great data mining efforts, on a much broader scale than what has been done so far. For example, a former colleague of mine used the correlation of published drug side effects between different drugs [1] to predict potential alternative therapeutic targets.
Getting all the data on drug efficacy, availability, correlate it with chemical structure, combine it with the information on other drugs could potentially help us a lot in predicting better working future drugs and the workings of existing drugs.
Also, transparency. No more picking out those trials that worked and conveniently forgetting about those that did not work.
[1] https://www.sciencemag.org/content/321/5886/263.abstract
Re: Europe votes for clinical trial transparency
#6> • Require that a summary understandable to a lay person of what was found in the trial is published on the register. Good luck with that. Explaining complex cellular mechanisms to a lay person without any scientific nor statistical background is a very difficult task. When you consider modern medicine, you need basic knowledge in genetics, biochemistry, biology, proteins, drug formulation, pharmacology, pharmadynam…
It might not be possible in every case, but it sounds like a laudable goal to me.
Also, what do they tell people who take part in trials - I'd be pretty annoyed if I took part in a trial and someone told me "we can't tell you because with your humble CS education you wouldn't understand it".
Re: Europe votes for clinical trial transparency
#7Both "Bad Pharma" and "Bad Science" are excellent books - strongly recommended: http://en.wikipedia.org/wiki/Bad_Pharma http://en.wikipedia.org/wiki/Bad_Science_%28book%29 I wonder if you can get "I am a Nutritionist!" T-shirts? [Edit: Thanks for pointing out the T-Shirt pretty much does exist].
He sells shirts picturing a rubber ducky with "nutritionist" printed underneath: http://badscience2.spreadshirt.co.uk/sophisticated-visual-ga...
Congrats to ben goldacre and everyone else who worked on this!
Re: Europe votes for clinical trial transparency
#8> • Require that a summary understandable to a lay person of what was found in the trial is published on the register. Good luck with that. Explaining complex cellular mechanisms to a lay person without any scientific nor statistical background is a very difficult task. When you consider modern medicine, you need basic knowledge in genetics, biochemistry, biology, proteins, drug formulation, pharmacology, pharmadynam…
Well, a trial is not about the molecular mechanisms of a drug. It is about checking whether a drug works and whether it is better than existing drugs. So statistics.
Still hard, obviously, and plenty of space for semantic whitewashing.
Re: Europe votes for clinical trial transparency
#9Both "Bad Pharma" and "Bad Science" are excellent books - strongly recommended: http://en.wikipedia.org/wiki/Bad_Pharma http://en.wikipedia.org/wiki/Bad_Science_%28book%29 I wonder if you can get "I am a Nutritionist!" T-shirts? [Edit: Thanks for pointing out the T-Shirt pretty much does exist].
He sells shirts picturing a rubber ducky with "nutritionist" printed underneath: http://badscience2.spreadshirt.co.uk/sophisticated-visual-ga... Congrats to ben goldacre and everyone else who worked on this!
[deleted]
Re: Europe votes for clinical trial transparency
#10> • Require that a summary understandable to a lay person of what was found in the trial is published on the register. Good luck with that. Explaining complex cellular mechanisms to a lay person without any scientific nor statistical background is a very difficult task. When you consider modern medicine, you need basic knowledge in genetics, biochemistry, biology, proteins, drug formulation, pharmacology, pharmadynam…
>> • Require that a summary understandable to a lay person of what was found in the trial is published on the register.
>Good luck with that. Explaining complex cellular mechanisms to a lay person without any scientific nor statistical background is a very difficult task.
I don't think that the cellular mechanisms, or generally speaking the mode of action, are what has to be explained understandable to a lay person. What has to be explained is the result of the trial.