Pathogen from gut of obese human causes obesity in germfree mice
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Re: Pathogen from gut of obese human causes obesity in germfree mice
#2The article is very interesting. I looked, but couldn't find information on the exact diet of the test subject during the study. Did anybody else have any better luck?
Re: Pathogen from gut of obese human causes obesity in germfree mice
#3Two interesting notes from the abstract:
"The endotoxin-producing Enterobacter decreased in relative abundance from 35% of the volunteer’s gut bacteria to non-detectable, during which time the volunteer lost 51.4 kg of 174.8 kg initial weight and recovered from hyperglycemia and hypertension after 23 weeks on a diet of whole grains, traditional Chinese medicinal foods and prebiotics."
"The obesity-inducing capacity of this human-derived endotoxin producer in gnotobiotic mice suggests that it may causatively contribute to the development of obesity in its human host."
Re: Pathogen from gut of obese human causes obesity in germfree mice
#4Great, another article for fat acceptance idiots to read the title of and declare it cake day.
> The volunteer lost 30.1 kg after 9 weeks, and 51.4 kg after 23 weeks, on a diet composed of whole grains, traditional Chinese medicinal foods and prebiotics (WTP diet, Supplementary Information; Supplementary Figure 1), with continued amelioration of hyperinsulinemia, hyperglycemia and hypertension until most metabolic parameters improved to normal ranges (Table 1). After 9 weeks on the WTP diet, this Enterobacter population in the volunteer's gut reduced to 1.8%, and became undetectable by the end of the 23-week trial, as shown in the clone library analysis (Table 1; Supplementary Figures 2 and 3).
Re: Pathogen from gut of obese human causes obesity in germfree mice
#5The article is very interesting. I looked, but couldn't find information on the exact diet of the test subject during the study. Did anybody else have any better luck?
The supplementary information link at the bottom has a link to the diet and how it was prepared:
Dietary intervention and sampling. This volunteer was given a diet composed of whole grains, traditional Chinese medicine and prebiotics (WTP diet) for intervention. He was given 4 cans of gruel per day as staple food contract prepared in the form of cooked porridge (370 g wet weight per can) then canned by a food manufacturer (Shanghai Meilin Meida Food Co., Ltd.) for 23 weeks. Each can contained 100 g dry ingredients (59 g of carbohydrate, 15 g of protein, 5 g of fat, and 6 g of fiber) providing 336 kcal energy (70 % of carbohydrate, 17 % of protein, 13 % of fat). Fresh fecal samples were collected with 4 or 5 weeks intervals. Whole blood and serum samples were collected with 0, 9 and 23 week (0d, 9w, 23w). All samples were immediately frozen on collection and stored at -80 °C for subsequent analysis.
Re: Pathogen from gut of obese human causes obesity in germfree mice
#6The article is very interesting. I looked, but couldn't find information on the exact diet of the test subject during the study. Did anybody else have any better luck?
The supplementary information link at the bottom has a link to the diet and how it was prepared: Dietary intervention and sampling. This volunteer was given a diet composed of whole grains, traditional Chinese medicine and prebiotics (WTP diet) for intervention. He was given 4 cans of gruel per day as staple food contract prepared in the form of cooked porridge (370 g wet weight per can) then canned by a food manufac…
So, only 1344 cals per day.
Re: Pathogen from gut of obese human causes obesity in germfree mice
#7Earlier quoted context omitted.
The supplementary information link at the bottom has a link to the diet and how it was prepared: Dietary intervention and sampling. This volunteer was given a diet composed of whole grains, traditional Chinese medicine and prebiotics (WTP diet) for intervention. He was given 4 cans of gruel per day as staple food contract prepared in the form of cooked porridge (370 g wet weight per can) then canned by a food manufac…
So, only 1344 cals per day.
One can argue it was the calorie restriction and not the bacteria. However, the interesting part was that the pathogen then caused the mice to gain weight.
Re: Pathogen from gut of obese human causes obesity in germfree mice
#8Great, another article for fat acceptance idiots to read the title of and declare it cake day. > The volunteer lost 30.1 kg after 9 weeks, and 51.4 kg after 23 weeks, on a diet composed of whole grains, traditional Chinese medicinal foods and prebiotics (WTP diet, Supplementary Information; Supplementary Figure 1), with continued amelioration of hyperinsulinemia, hyperglycemia and hypertension until most metabolic pa…
You're right, we should all lament the possible passing of another way of judging people inferior to us.
Re: Pathogen from gut of obese human causes obesity in germfree mice
#9Ok, this is an interesting observation:
"After 9 weeks on the WTP diet, this Enterobacter population in the volunteer's gut reduced to 1.8%, and became undetectable by the end of the 23-week trial"
So the thesis is that this bacteria lives in obese people's gut, and it makes them more obese. But once they diet to a point where they are not obese, the bacteria dies off? I wonder if they are going to try a diet + anti-biotic treatment, diet + placebo trial on two obese patients to see if it improves their chances to get back into a regular balance.
Re: Pathogen from gut of obese human causes obesity in germfree mice
#10Great, another article for fat acceptance idiots to read the title of and declare it cake day. > The volunteer lost 30.1 kg after 9 weeks, and 51.4 kg after 23 weeks, on a diet composed of whole grains, traditional Chinese medicinal foods and prebiotics (WTP diet, Supplementary Information; Supplementary Figure 1), with continued amelioration of hyperinsulinemia, hyperglycemia and hypertension until most metabolic pa…
You're right, we should all lament the possible passing of another way of judging people inferior to us.
He missed the part where Monsanto makes a weaponized form of the bacteria that you use against your enemies to make them fat.