Enhancing gut-brain communication reversed cognitive decline in aging mice
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Re: Enhancing gut-brain communication reversed cognitive decline in aging mice
#2... in mice. So if any of this held in humans, I think you'd see reversal of old-age memory problems in people treated with antibiotics that kill Parabacteroides goldsteinii.
As far as I know, no such effect has been observed.
And this article claims inflamation from that strain, the NIH claims otherwise: "Parabacteroides goldsteinii is a next-generation probiotic gut bacterium with significant anti-inflammatory and metabolic benefits, often reduced in obese or diseased states. "
Re: Enhancing gut-brain communication reversed cognitive decline in aging mice
#3[flagged]
Re: Enhancing gut-brain communication reversed cognitive decline in aging mice
#4[flagged]
in mice is clearly in the subhead.
The connection between gut-brain has been studied in humans, as well as the effect of diet and gut bacteria on brain functions.
Re: Enhancing gut-brain communication reversed cognitive decline in aging mice
#5I smell bad data. This sounds too good to be true and most studies of this kind have turned out to be false a few years down the line.
Edit: one of many examples: https://www.science.org/content/article/journal-retracts-inf...
Re: Enhancing gut-brain communication reversed cognitive decline in aging mice
#6[flagged]
in mice is clearly in the subhead. The connection between gut-brain has been studied in humans, as well as the effect of diet and gut bacteria on brain functions.
And in this case it sounds like the pathway to determining if this has an effect in humans as well might be relatively short given there is a pool of patients receiving vagus nerve stimulation for other things that might provide data.
Re: Enhancing gut-brain communication reversed cognitive decline in aging mice
#7Mice mice mice. Tell me when you test on humans
Re: Enhancing gut-brain communication reversed cognitive decline in aging mice
#8... in mice. So if any of this held in humans, I think you'd see reversal of old-age memory problems in people treated with antibiotics that kill Parabacteroides goldsteinii. As far as I know, no such effect has been observed. And this article claims inflamation from that strain, the NIH claims otherwise: "Parabacteroides goldsteinii is a next-generation probiotic gut bacterium with significant anti-inflammatory and…
It's possible the specifics are different but that the overall idea still could work for humans. It seems worth at least exploring.
Re: Enhancing gut-brain communication reversed cognitive decline in aging mice
#9Everyone's "poo-pooing" the article because the title doesn't mention mice, but, FWIW, stories of gut biota affecting humans behavior have been documented for a while.
Memory gain is noteworthy, which is the article's "wow" factor, but everyone's just knee-jerk smirking so ... here's a few random articles to gross you out about the wild world of trading microbiota and, for better or worse, changing your personality:
* "My butt made me crave candy."[1]
* "Gee, I'm not bipolar anymore thanks to my husband's butt juice infusion."[2]
[1] https://www.psychologytoday.com/us/blog/the-behavioral-microbiome/202404/hacking-an-individuals-personality-through-their-gut-contents
[2] https://www.abc.net.au/news/2025-07-28/faecal-microbiota-transplant-credited-with-curing-bipolar/105541522Re: Enhancing gut-brain communication reversed cognitive decline in aging mice
#10Everyone's "poo-pooing" the article because the title doesn't mention mice, but, FWIW, stories of gut biota affecting humans behavior have been documented for a while. Memory gain is noteworthy, which is the article's "wow" factor, but everyone's just knee-jerk smirking so ... here's a few random articles to gross you out about the wild world of trading microbiota and, for better or worse, changing your personality:…
I would recommend the site https://gutbrainaxistherapeutics.com for learning more about Microbiota Transplant Therapy (MTT) and its opportunities, especially for Autism and Pitt-Hopkins Syndrome.