The Molecular Basis of Long Covid Brain Fog
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The Molecular Basis of Long Covid Brain Fog
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Re: The Molecular Basis of Long Covid Brain Fog
#2Very cool. Surprising that having more AMPA receptors would lead to decreased cognition, as learning & memory is hypothesized to particularly involve processes that increase the number of in-position AMPA receptors.
Re: The Molecular Basis of Long Covid Brain Fog
#3There's so much we don't know about this yet. It's great to see new knowledge being generated! I had Covid last February (vaccinated and boosted, thankfully). It was a mild course, but I wound up sensitized to caffeine for three to four months after.
I normally drink 100-150mg/day, but I had to cut that back to 50-60mg and only in the morning. It seems to have passed, so I'm back on my drip.
Re: The Molecular Basis of Long Covid Brain Fog
#4The headline overstates the findings. The researchers aren't saying that this is the underlying basis of COVID brain fog. They hypothesized that AMPA receptors might be involved. They compared Long COVID patients to controls and found a difference.
This doesn't mean that AMPA receptors are the root cause of post-COVD brain fog, nor does it necessarily mean that drugs modulating AMPA receptors could reverse it. It only shows that this is one of the changes observed in patients reporting post-COVID brain fog. It could be a side effect of some other change or it could be part of a long cascade of changes.
It also needs to be replicated further. I've read at least at dozen headlines claiming to have found the underlying cause of COVID brain fog in the past year and all of them pointed to different biomarkers.
Consider this another piece of the puzzle, not a discovery of the underlying mechanism.
Re: The Molecular Basis of Long Covid Brain Fog
#5Very cool. Surprising that having more AMPA receptors would lead to decreased cognition, as learning & memory is hypothesized to particularly involve processes that increase the number of in-position AMPA receptors.
> Surprising that having more AMPA receptors would lead to decreased cognition
The study only looked at one marker. It doesn't confirm that increased AMPA receptor density is the cause of decreased cognition. It only suggests that decreased cognition is correlated with increased AMPA receptor density.
There are many processes in the body where reduced activation of a receptor system results in an increased number of those receptors. So don't conclude that this is the reason why patients have brain fog. I would guess it's just more of a symptom than a cause until there's more research
Re: The Molecular Basis of Long Covid Brain Fog
#6The biggest impact I've made on my brain fog (post COVID) is using nicotine. Even 2mg a day makes a big difference for me.
Re: The Molecular Basis of Long Covid Brain Fog
#7The biggest impact I've made on my brain fog (post COVID) is using nicotine. Even 2mg a day makes a big difference for me.
What do you do for managing dependency / tolerance?
Re: The Molecular Basis of Long Covid Brain Fog
#8There's so much we don't know about this yet. It's great to see new knowledge being generated! I had Covid last February (vaccinated and boosted, thankfully). It was a mild course, but I wound up sensitized to caffeine for three to four months after. I normally drink 100-150mg/day, but I had to cut that back to 50-60mg and only in the morning. It seems to have passed, so I'm back on my drip.
I had the same thing with my caffeine sensitivity, but my nicotine sensitivity hasn’t gone back and it’s been over a year. I used nicotine lozenges daily for years but even after 12 months post-covid my body does not tolerate them.
Re: The Molecular Basis of Long Covid Brain Fog
#9The headline overstates the findings. The researchers aren't saying that this is the underlying basis of COVID brain fog. They hypothesized that AMPA receptors might be involved. They compared Long COVID patients to controls and found a difference. This doesn't mean that AMPA receptors are the root cause of post-COVD brain fog, nor does it necessarily mean that drugs modulating AMPA receptors could reverse it. It onl…
Thanks. I love this comments that spare time for everybody else. But honestly, anything biology/medicine related, you KNOW the title is exaggerated, right out of the bat
Re: The Molecular Basis of Long Covid Brain Fog
#10The biggest impact I've made on my brain fog (post COVID) is using nicotine. Even 2mg a day makes a big difference for me.
What do you do for managing dependency / tolerance?
Sometimes I take the weekends off. Also I get irritable if I don't get enough sleep AND not enough nicotine. It's a trade-off.
As for tolerance, I haven't noticed the brain fog come back since I started, and I've been on this for 6 or 8 months so far.