Scientists may have found a way to eliminate chromosome linked to Down syndrome
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Re: Scientists may have found a way to eliminate chromosome linked to Down syndrome
#2This will never go to human trial.
Re: Scientists may have found a way to eliminate chromosome linked to Down syndrome
#3This will never go to human trial.
Probably not this specific method, no. Even the paper abstract notes that this is stepping-stone research.
Re: Scientists may have found a way to eliminate chromosome linked to Down syndrome
#4I don't really understand what it says. As a layman in this topic, I'm curious if modifications like that can cause other effects?
Re: Scientists may have found a way to eliminate chromosome linked to Down syndrome
#5This is interesting news, for the lack of a better word. I've met more than one person with downs syndrome. They have definitely enriched my life and shown me a different way of looking at the world.
Re: Scientists may have found a way to eliminate chromosome linked to Down syndrome
#6I don't really understand what it says. As a layman in this topic, I'm curious if modifications like that can cause other effects?
Hard to say with 100% certainty without a human trial, but the short answer is "probably not." This is a situation where a person has three copies of chromosome 21 in every cell. Shutting one copy down would, hypothetically, leave someone with two working copies. I don't think we have any reason to believe that trisomy is masking some other phenomenon that we won't see until a fetus with this treatment applied fully develops into a newborn.
(And that's of course assuming human trials were authorized. Probably not for this treatment in my lifetime, at least not in the US).
Re: Scientists may have found a way to eliminate chromosome linked to Down syndrome
#7This is interesting news, for the lack of a better word. I've met more than one person with downs syndrome. They have definitely enriched my life and shown me a different way of looking at the world.
What's better for them should be the overriding concern and that's to have a normal development.
Re: Scientists may have found a way to eliminate chromosome linked to Down syndrome
#8This will never go to human trial.
They definitely will in China or Russia
Re: Scientists may have found a way to eliminate chromosome linked to Down syndrome
#9I don't really understand what it says. As a layman in this topic, I'm curious if modifications like that can cause other effects?
It says that they've developed a way to identify the extra chromosome(s) passed to a child by a malfunctioning germ cell, specifically chromosome 21 though presumably this method could be reproduced for other trisomy diseases. This could, most immediately, lead to a therapy that allows a couple that is going through in vitro fertilization to repair a zygote that has trisomy by correcting the number of chromosomes it has, and preventing the resulting child from having Down's syndrome. This is relevant especially for older mothers, who are most likely to produce malfunctioning eggs that result in Down's syndrome
Re: Scientists may have found a way to eliminate chromosome linked to Down syndrome
#10Interesting, I wonder what else this might lead too! Encouraging we might be getting somewhere.
I used to live near a Down syndrome center where a bunch of folks lived and I remember this one lady who was kitted out with Britney Spears everything, lunchbox, t-shirt, hat, and headphones. Everyday I passed by the bus stop she would be dancing her heart out to a Britney track waiting for the bus and it made my world a little brighter.