Molecule produced by gut bacteria causes atherosclerosis
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Molecule produced by gut bacteria causes atherosclerosis
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Re: Molecule produced by gut bacteria causes atherosclerosis
#2I wonder how much of our diet contributes to these gut microbes?
Re: Molecule produced by gut bacteria causes atherosclerosis
#3Atherosclerosis is, as I’ve read, a major cause of age related disease and death, so finding a cause and solution like this could be a major advancement in increasing healthspan. Another step toward longevity escape velocity.
Re: Molecule produced by gut bacteria causes atherosclerosis
#4I wonder how much of our diet contributes to these gut microbes?
My immediate thought was "well, what do these bacteria feed on?".
Re: Molecule produced by gut bacteria causes atherosclerosis
#5Paid for by taxpayers via 37 academic grants and fellowships primarily from the EU. Minority contributions are from the US (NIH). One corporation (Santander Bank).
Re: Molecule produced by gut bacteria causes atherosclerosis
#6I wonder how much of our diet contributes to these gut microbes?
My immediate thought was "well, what do these bacteria feed on?".
A quick Google search reveals these bacteria produce the imidazole propionate from histidine. Unfortunately, histidine is an essential amino acid (necessary for life and our bodies can't produce it so we need it in our diet).
Re: Molecule produced by gut bacteria causes atherosclerosis
#7 "The new study shows that blood levels of imidazole propionate
are lower in people with diets rich in vegetables, fruits, whole grains, fish,
tea, and low-fat dairy products."
Re: Molecule produced by gut bacteria causes atherosclerosis
#8"A team of Spanish scientists made a striking announcement 15 years ago: they were seeking thousands of volunteers among the employees of Banco Santander in Madrid: researchers wanted to study them in depth for decades, in order to understand the onset of cardiovascular disease in healthy people."
Is there a project like this one can join in the US? I've always wanted to contribute to a biomedical study.
Re: Molecule produced by gut bacteria causes atherosclerosis
#9The same metabolite, imidazole propionate (ImP), was already found to be associated with diabetes and heart failure. See for example this study in Nature Communications (2020): https://www.nature.com/articles/s41467-020-19589-w.
I think the value of the current study in Nature is that "ImP administration to atherosclerosis-prone mice fed with chow diet was sufficient to induce atherosclerosis without altering the lipid profile, and was linked to activation of both systemic and local innate and adaptive immunity and inflammation.", i.e. they provided evidence of causality in a mechanistic way, with an intervention.
However, the newspaper article overplayed novelty. ImP and other metabolites from gut bacteria have already been linked to atherosclerosis.
Re: Molecule produced by gut bacteria causes atherosclerosis
#10"A team of Spanish scientists made a striking announcement 15 years ago: they were seeking thousands of volunteers among the employees of Banco Santander in Madrid: researchers wanted to study them in depth for decades, in order to understand the onset of cardiovascular disease in healthy people." Is there a project like this one can join in the US? I've always wanted to contribute to a biomedical study.
You could look for specific studies on clinialtrials.gov. Its a database of trials in the US and also around the world. In the US I'm not sure of the status of such studies about budget cuts to NIH.
I myself was on 1 year study post organ transplant for impact of whole grain plant based diet. They educate you initially on the diet and then monitor your weight and blood tests over the year.