It took my savings and 14 years but I’m about to beat arthritis
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Re: It took my savings and 14 years but I’m about to beat arthritis
#2Re: It took my savings and 14 years but I’m about to beat arthritis
#3If true, what an amazing discovery.
Re: It took my savings and 14 years but I’m about to beat arthritis
#4Headline seems a bit overdone. The drug completed Phase 1 trials. Roughly 14% of successful P1 trials eventually get approved. It'll be probably another 5-10 years before this finishes P3.
Re: It took my savings and 14 years but I’m about to beat arthritis
#5Headline seems a bit overdone. The drug completed Phase 1 trials. Roughly 14% of successful P1 trials eventually get approved. It'll be probably another 5-10 years before this finishes P3.
Not sure what article you read. Phase II trials just wrapped up and showed both tolerability and effectiveness, hitting primary endpoints. Phase III is apparently recruiting, which should reveal any showstopper side effects in a larger and more diverse population. It’s realistic this could hit the market in 3-5 years or less.
Additional info: https://www.fiercebiotech.com/biotech/british-biotech-levice...
Re: It took my savings and 14 years but I’m about to beat arthritis
#6Headline seems a bit overdone. The drug completed Phase 1 trials. Roughly 14% of successful P1 trials eventually get approved. It'll be probably another 5-10 years before this finishes P3.
It completed Phase 2 trials according to the article. I don't know the rates of P2 trials getting to approval, but he's past safety and initial efficacy in over 510 patients (510 seems to have been only the last trial, so doesn't include P1, which would be significantly smaller).
Re: It took my savings and 14 years but I’m about to beat arthritis
#7The title is misleading. It's not a "cure for Arthritis"; it's a pain killer.
Re: It took my savings and 14 years but I’m about to beat arthritis
#8The title is misleading. It's not a "cure for Arthritis"; it's a pain killer.
This is true, although it looks like in this case it may be more useful than just another pain killer, in that if you can reduce the joint pain, people might be more active, which may help them lose weight, which may reduce joint pain. If it's safe to take long term (reading between the lines, sounds like it might be compared to other pain killers), then it could have lasting impact on patients beyond them taking it, which is a good thing.
Re: It took my savings and 14 years but I’m about to beat arthritis
#9The title is misleading. It's not a "cure for Arthritis"; it's a pain killer.
Not quite.
> The drug is based on a molecule he discovered while working at Pfizer, and can be delivered via a once-a-month EpiPen-style injection, where it restores protective processes to diseased joints and enables the regeneration of affected tissues. It works by blocking a compound that supports the nerve cells involved in transmitting pain signals to the brain.
The mechanism might be to affect the nerve cells involved in pain signaling, but the effect is to actually help regenerate tissue.
Re: It took my savings and 14 years but I’m about to beat arthritis
#10The title is misleading. It's not a "cure for Arthritis"; it's a pain killer.
Not quite. > The drug is based on a molecule he discovered while working at Pfizer, and can be delivered via a once-a-month EpiPen-style injection, where it restores protective processes to diseased joints and enables the regeneration of affected tissues. It works by blocking a compound that supports the nerve cells involved in transmitting pain signals to the brain. The mechanism might be to affect the nerve cells i…
Fantastic, but the title is still misleading.
> It is hoped the drug — which is not a cure but will make the condition much less painful for sufferers [...]