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Gene therapy restores hearing to children with inherited deafness

cosmosmagazine.com

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Re: Gene therapy restores hearing to children with inherited deafness

#2
This stuff seems miraculous.

> "Through minimally invasive surgery, Shu injected adeno-associated virus (AAV) engineered to carry and deliver functioning copies of the human OTOF transgene, into the children’s inner ears. "

Can't read that and not get curious, excited, for the future.

Congratulations to all those involved in the research and thanks to all who contributed to it - including all taxpayers if public funding was given, even indirectly (i.e. in the schooling and education, grants, for said researchers)

Re: Gene therapy restores hearing to children with inherited deafness

#4

Wait until they have kids. The deafness gene will be passed along. Soon enough we'll be like the cars with the hardware without the software or the locked features.

We have this already. As a species we are susceptible to many diseases which we have to take vaccines for, every generation.

Re: Gene therapy restores hearing to children with inherited deafness

#5

Wait until they have kids. The deafness gene will be passed along. Soon enough we'll be like the cars with the hardware without the software or the locked features.

Fortunately won't be a big issue, as:

>OTOF-related deafness is inherited in an autosomal recessive manner. If both parents are known to be carriers, each sib of an individual with OTOF-related deafness has at conception a 25% chance of being deaf, a 50% chance of having normal hearing and being a carrier, and a 25% chance of having normal hearing and not being a carrier.

source: https://www.ncbi.nlm.nih.gov/books/NBK1251/

Re: Gene therapy restores hearing to children with inherited deafness

#6

Wait until they have kids. The deafness gene will be passed along. Soon enough we'll be like the cars with the hardware without the software or the locked features.

How is this any different from people who suffer from other genetic disorders that we have treatments for? Or people who just suffer from a chronic disease that requires regular treatments/medication for them to stay alive/health? (HIV, Diabetes, etc)

Re: Gene therapy restores hearing to children with inherited deafness

#7
post #4

Wait until they have kids. The deafness gene will be passed along. Soon enough we'll be like the cars with the hardware without the software or the locked features.

We have this already. As a species we are susceptible to many diseases which we have to take vaccines for, every generation.

I don't think susceptibility to viral diseases like measles is typically regarded as a genetic defect, is it? Any more than being flammable is a genetic defect, anyway.
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