Effect of gut microbiome modulation on muscle function and cognition

> Resistant starch does not release glucose within the small intestine, but rather reaches the large intestine where it is consumed or fermented by colonic bacteria (gut microbiota).

... or whose starch converts to resistant starch when cooling down. Happens with the starch from potatoes, rice etc. And some of the delicious recipes of https://www.youtube.com/@YEUNGMANCOOKING should work fine (mainly plant based stuff). But have a steak or whatever you like best every now and then too, your microbiome will live with that, as long as it gets its preferred nutrients often enough. ;-)

Re: Effect of gut microbiome modulation on muscle function and cognition

#6

Post by bicijay » Mon, Mar 04, 2024, 5:33 PM UTC

JPLeRouzic wrote: post #3

When reading table 3, I am wrong to think the improvement occurred in both branches of the clinical trial and only marginal? For example: Pattern recognition memory test (% correct) * At Baseline: Treatment branch :86 (12%) Placebo branch :91 (9%) * At study End: Treatment branch :97 (7%) Placebo branch :93 (7%) https://www.nature.com/articles/s41467-024-46116-y/tables/3

Treatment Branch = 86.74 -> 97.44 => 12.33% increase

Placebo Branch = 91.32 -> 93.59 => 2.48% increase

Unless im reading it wrong, it seems like a 10% difference between both. Which in my books is not "marginal".

Re: Effect of gut microbiome modulation on muscle function and cognition

#7

Post by bicijay » Mon, Mar 04, 2024, 5:34 PM UTC

epgui wrote: post #4

throwwwwwwaw wrote: post #2

So what should I eat now?

A diverse diet with lots of plants, vegetables and fiber. This doesn’t change that.

What about fermented food?

Re: Effect of gut microbiome modulation on muscle function and cognition

#8

Post by agos » Mon, Mar 04, 2024, 5:40 PM UTC

bicijay wrote: post #7

epgui wrote: post #4

Earlier quoted context omitted.

A diverse diet with lots of plants, vegetables and fiber. This doesn’t change that.

What about fermented food?

that's a bit broad, as it includes sauerkraut, bread, cheese and beer.

Re: Effect of gut microbiome modulation on muscle function and cognition

#9

Post by caycep » Mon, Mar 04, 2024, 5:51 PM UTC

the last time I looked at microbiome stuff, someone at Stanford tried to chop up all the microbes in poop and sequence all the RNA/DNA sequences they could collect from that soup. It amounted to several petabytes of data or something ridiculous. Has anyone come up w/ a better way of analysis?

Re: Effect of gut microbiome modulation on muscle function and cognition

#10

Post by humbleferret » Mon, Mar 04, 2024, 5:58 PM UTC

This was an interesting read.

In essence, a randomised controlled trial looked at the effects of gut microbiome modulation on muscle function and cognition in older adults. Participants in the trail received either a prebiotic or a placebo.

My takeaways: - The prebiotic improved cognitive function, but not muscle function, for members of the trial.

- The gut microbiome composition changed in the prebiotic group, with an increase in Bifidobacterium abundance. (Was not clear on a first read if that is necessarily always positive).

- The trial suggests that microbiome modulation might be a target for improving cognitive function in older adults.

- Prebiotics the trial mentions: inulin and FOS