Nasopharyngeal Lymphatics Found to Be Crucial for Cerebrospinal Fluid Outflow
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Re: Nasopharyngeal Lymphatics Found to Be Crucial for Cerebrospinal Fluid Outflow
#2> We aim to investigate in a reliable animal model whether activating the cervical lymphatic vessels through pharmacological or mechanical means can prevent the exacerbation of Alzheimer’s disease progression by improving CSF clearance.
Any speculation on what those mechanical means might be?
Re: Nasopharyngeal Lymphatics Found to Be Crucial for Cerebrospinal Fluid Outflow
#3In mice;
and there are some anatomical differences between mice and humans..
So its open at this point whether it is relevant directly to humans.
IIRC, mice do not get Alzheimer’s, for instance. There are mouse models (genetically engineered)that exhibit some of the physiological symptoms of Alzheimer’s; but mice make particularly poor models for human neurology [1]- so this reach for using these essentially biomechanical structures to identify parallels and try to target a cure for neuro-degerative disorders in humans: seems more like a grant application attempt. I do wish press releases were a little more circumspect about such claims.
[1] https://www.statnews.com/2019/04/16/trouble-mice-behavioral-...
Re: Nasopharyngeal Lymphatics Found to Be Crucial for Cerebrospinal Fluid Outflow
#4Fascinating. Maybe I’m misunderstanding, but I immediately have questions about whether sleep quality links with neurodegenerative disease are instead a symptom of sleep apnea via reduced lymphatic stimulation and not sleep itself. Could diet impact it, not by the composition of the food, but by consistency and how much chewing is involved. Could chewing gum make a difference? Neck exercises? I wonder if there is a correlation with people who mouth breathe or clench their teeth at night.
Re: Nasopharyngeal Lymphatics Found to Be Crucial for Cerebrospinal Fluid Outflow
#5> We aim to investigate in a reliable animal model whether activating the cervical lymphatic vessels through pharmacological or mechanical means can prevent the exacerbation of Alzheimer’s disease progression by improving CSF clearance. Any speculation on what those mechanical means might be?
Ultrasound?
Re: Nasopharyngeal Lymphatics Found to Be Crucial for Cerebrospinal Fluid Outflow
#6[flagged]
Re: Nasopharyngeal Lymphatics Found to Be Crucial for Cerebrospinal Fluid Outflow
#7> We aim to investigate in a reliable animal model whether activating the cervical lymphatic vessels through pharmacological or mechanical means can prevent the exacerbation of Alzheimer’s disease progression by improving CSF clearance. Any speculation on what those mechanical means might be?
sounds like https://en.wikipedia.org/wiki/Manual_lymphatic_drainage
it feels great when you're sick, but in an ideal state, you should not need to do this as your system should be able to self-drain
Re: Nasopharyngeal Lymphatics Found to Be Crucial for Cerebrospinal Fluid Outflow
#8In mice; and there are some anatomical differences between mice and humans.. So its open at this point whether it is relevant directly to humans. IIRC, mice do not get Alzheimer’s, for instance. There are mouse models (genetically engineered)that exhibit some of the physiological symptoms of Alzheimer’s; but mice make particularly poor models for human neurology [1]- so this reach for using these essentially biomecha…
They do say they plan to verify findings in primates as well so perhaps the accomplishment here is more concerning the methodology. So there me be some greater merit to this work going forward.
I think it would be more interesting for this kind of study to verify these measures that can only be obtained in animals with neuroimaging. There have been some interesting attempts to move monitor aspects of CSF flow through MRI but we need to make sure we are measuring what we think we are before using in the clinic
Re: Nasopharyngeal Lymphatics Found to Be Crucial for Cerebrospinal Fluid Outflow
#9Oh. I thought this was posted for its title, reminiscent of the best of grindcore and death metal bands.
Re: Nasopharyngeal Lymphatics Found to Be Crucial for Cerebrospinal Fluid Outflow
#10> We aim to investigate in a reliable animal model whether activating the cervical lymphatic vessels through pharmacological or mechanical means can prevent the exacerbation of Alzheimer’s disease progression by improving CSF clearance. Any speculation on what those mechanical means might be?
sounds like https://en.wikipedia.org/wiki/Manual_lymphatic_drainage it feels great when you're sick, but in an ideal state, you should not need to do this as your system should be able to self-drain
It also forms a large part of the Perrin Technique which aims to treat chronic fatigue syndrome (AKA CFS/ME).