'It's all gone': CAR-T therapy forces autoimmune diseases into remission
1–10 of 34 posts
Re: 'It's all gone': CAR-T therapy forces autoimmune diseases into remission
#2> CAR-T therapy can have severe side effects, and recipients must first undergo intensive chemotherapy that kills off many of their existing immune cells.
Damn, that really seems like a last resort.
Re: 'It's all gone': CAR-T therapy forces autoimmune diseases into remission
#3> CAR-T therapy can have severe side effects, and recipients must first undergo intensive chemotherapy that kills off many of their existing immune cells. Damn, that really seems like a last resort.
I understand that is similar to any chemotherapy no? But your body will rebuild it after ˜30days.
Re: 'It's all gone': CAR-T therapy forces autoimmune diseases into remission
#4> CAR-T therapy can have severe side effects, and recipients must first undergo intensive chemotherapy that kills off many of their existing immune cells. Damn, that really seems like a last resort.
chemo is well known for the treatment being worse than the disease...in the short term. when it works, the long term effect is well worth it.
Re: 'It's all gone': CAR-T therapy forces autoimmune diseases into remission
#5> CAR-T therapy can have severe side effects, and recipients must first undergo intensive chemotherapy that kills off many of their existing immune cells. Damn, that really seems like a last resort.
> that really seems like a last resort
Have we had a compelling reason to research drugs whose primary purpose is to kill bone marrow in healthy patients before?
Re: 'It's all gone': CAR-T therapy forces autoimmune diseases into remission
#6As a carrier of another autoimmune disease, I will be tempted to flip that switch should it become available. Since I participate in pretty much all studies they offer me, I would consider joining that one too. It might be the last one they'd ask me in for!
On the other hand, the disease is not debilitating for me. I'll also consider waiting and let a few fellow diabetics try first :-)
Re: 'It's all gone': CAR-T therapy forces autoimmune diseases into remission
#7What about leukemias?
Re: 'It's all gone': CAR-T therapy forces autoimmune diseases into remission
#8I have an autoimmune disease mentioned in the article. In looking through a group of which I am member I came across this interesting FDA alert about CAR-T therapy from a few weeks ago...
https://www.drugs.com/fda/fda-investigating-serious-risk-t-c...
Re: 'It's all gone': CAR-T therapy forces autoimmune diseases into remission
#9> CAR-T therapy can have severe side effects, and recipients must first undergo intensive chemotherapy that kills off many of their existing immune cells. Damn, that really seems like a last resort.
chemo is well known for the treatment being worse than the disease...in the short term. when it works, the long term effect is well worth it.
Yeah, I wouldn't undergo chemo for something like eczema or a simple food intolerance, but if it were something like lupus or Guillain-Barré syndrome I would seriously consider it.
Re: 'It's all gone': CAR-T therapy forces autoimmune diseases into remission
#10What about leukemias?
That's what cd19 car t was already developed and FDA approved for