Scientists discover links between Alzheimer's disease and gut microbiota
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Re: Scientists discover links between Alzheimer's disease and gut microbiota
#2I had to triple check the date because I was pretty sure that this was known before. Maybe it is simply the confirmation aspect of it?
Edit:
> Our findings reveal for the first time, that Alzheimer’s symptoms can be transferred to a healthy young organism via the gut microbiota, *confirming a causal role* of gut microbiota in Alzheimer’s disease ...
From: https://faculty.sites.uci.edu/kimgreen/bio/glucocorticoids-a...
Citing many papers
> One early event in AD is an increase in circulating glucocorticoids
You could sum up Alzheimer's as: Diet/Lifestyle + a congenital form of Cushing's syndrome and you have increasing glucocorticoids which imply downregulation of the PVN, less progesterone and low levels of Prolactin reducing oligodendrocyte reducing myelin sheaths. Add in APOE e4 without choline in the diet and you have accumulation of lipids to round it all out.
There is a reason why Omega 3 + B+D vitamins are talked about as preventative as they all reduce inflamation.
See this for example: https://www.grassrootshealth.net/two-nutrients-proven-stop-b...
Edit2: For the curious here is a larger brain dump on the topic with many more links when I had to untangle the pathway earlier this year while working on something else. https://www.reddit.com/r/DrWillPowers/comments/16ae4zy/alzhe...
Re: Scientists discover links between Alzheimer's disease and gut microbiota
#3> For the first time, researchers have found that Alzheimer’s symptoms can be transferred to a healthy young organism via the gut microbiota, confirming its role in the disease.
I just read “I Contain Multitudes” by Ed Yong where this topic was unsure as there’s only a handful confirmed links to things like depression, obesity, etc. Now it is confirmed for Alzheimer’s. This is extraordinary.
Re: Scientists discover links between Alzheimer's disease and gut microbiota
#4I certainly hope they are going to replicate while knocking out one species of gut biota each time. Would be super helpful right?
Edit: Experiemental design
we establish indvidual colonies of each of the biota detected in our earlier work, we then recombine them in the ratios found in the original work and replicate the previous results.
We then creation combinations lacking a single organism from our mix and look for replication.
Finally we vary the percentages of the biota in our origianal mix and look to see if that affects our ability to replicate.
Re: Scientists discover links between Alzheimer's disease and gut microbiota
#5I certainly hope they are going to replicate while knocking out one species of gut biota each time. Would be super helpful right? Edit: Experiemental design we establish indvidual colonies of each of the biota detected in our earlier work, we then recombine them in the ratios found in the original work and replicate the previous results. We then creation combinations lacking a single organism from our mix and look fo…
except our bodies already kinda do that on their own
how would killing species of gut biota would helpful? helpful for whom to accomplish what??
we're headed to a future in which you have to take special pills so that the food doesn't kill you. like the glysophate and GMOs but applied against ALL life, including humans. if this is too far fetched for you then I also hope we don't get there.
Re: Scientists discover links between Alzheimer's disease and gut microbiota
#6I had to triple check the date because I was pretty sure that this was known before. Maybe it is simply the confirmation aspect of it? Edit: > Our findings reveal for the first time, that Alzheimer’s symptoms can be transferred to a healthy young organism via the gut microbiota, *confirming a causal role* of gut microbiota in Alzheimer’s disease ... From: https://faculty.sites.uci.edu/kimgreen/bio/glucocorticoids-a..…
For those that are curious and not well verse in research level biology, what kind of food, drink and lifestyle will help maintain a gut biome that prevent Alzheimer
Re: Scientists discover links between Alzheimer's disease and gut microbiota
#7> For the first time, researchers have found that Alzheimer’s symptoms can be transferred to a healthy young organism via the gut microbiota, confirming its role in the disease. I just read “I Contain Multitudes” by Ed Yong where this topic was unsure as there’s only a handful confirmed links to things like depression, obesity, etc. Now it is confirmed for Alzheimer’s. This is extraordinary.
It's an interesting avenue, though a problem is that updates and interviews with Ed Yong post book appear to show they could only treat one thing - c diff effectively with fecal transplants and that is apparently temporary, with recent studies show it lasting possibly a year before another transplant is necessary, and that probiotics via food like yogurt/kefir cultures only last as long as you eat the food regularly, there is no way (yet) to permanently fix a broken (as in the same as someone who had regular, non highly processed diet for baseline versus people who had switched from their pre highly processed diet to the highly processed modern diet) microbiome. Here's his Fresh Air interview, https://www.npr.org/2016/08/18/490432969/eating-yogurt-is-no... but he's written a lot of stuff since then, too, for the Atlantic.
Re: Scientists discover links between Alzheimer's disease and gut microbiota
#8I certainly hope they are going to replicate while knocking out one species of gut biota each time. Would be super helpful right? Edit: Experiemental design we establish indvidual colonies of each of the biota detected in our earlier work, we then recombine them in the ratios found in the original work and replicate the previous results. We then creation combinations lacking a single organism from our mix and look fo…
except our bodies already kinda do that on their own how would killing species of gut biota would helpful? helpful for whom to accomplish what?? we're headed to a future in which you have to take special pills so that the food doesn't kill you. like the glysophate and GMOs but applied against ALL life, including humans. if this is too far fetched for you then I also hope we don't get there.
> except our bodies already kinda do that on their own
> how would killing species of gut biota would helpful? helpful for whom to accomplish what??
OP wasn't talking about practical uses, he was talking about further experimentation in which the researchers narrow down exactly which gut bacteria has the effect.
Something like a binary search, or a git bisect.
Re: Scientists discover links between Alzheimer's disease and gut microbiota
#9I had to triple check the date because I was pretty sure that this was known before. Maybe it is simply the confirmation aspect of it? Edit: > Our findings reveal for the first time, that Alzheimer’s symptoms can be transferred to a healthy young organism via the gut microbiota, *confirming a causal role* of gut microbiota in Alzheimer’s disease ... From: https://faculty.sites.uci.edu/kimgreen/bio/glucocorticoids-a..…
sounds like prion disease:
https://en.wikipedia.org/wiki/Prion
EDIT: in the sense that it is similar
Re: Scientists discover links between Alzheimer's disease and gut microbiota
#10I had to triple check the date because I was pretty sure that this was known before. Maybe it is simply the confirmation aspect of it? Edit: > Our findings reveal for the first time, that Alzheimer’s symptoms can be transferred to a healthy young organism via the gut microbiota, *confirming a causal role* of gut microbiota in Alzheimer’s disease ... From: https://faculty.sites.uci.edu/kimgreen/bio/glucocorticoids-a..…
For those that are curious and not well verse in research level biology, what kind of food, drink and lifestyle will help maintain a gut biome that prevent Alzheimer
Fatty fish, most nuts (that don't have high omega-6, which is inflammatory), fruits high in antioxidants like berries and dark fruit in general, colorful vegetable, cooking with olive/avocado/sunflower oil, *kefir* which is the champion of all good microbiota inducers
As for avoiding: red meat (high in omega-6), gluten (chickpea, rice, lentil pasta instead of wheat), cooking with hydrogenated oils, preservatives, processed food, refined sugar
The lists could be much longer. Look up anti-inflammatory diet aka mediterranean diet. What I will say is adhering to this diet has done as much for my inflammatory condition as all the medication. With some foods I feel their effect right away (pork, too much sugar), with some it sneaks up as I let it slip for a few days. So I stand by it.