The complete sequence of a human Y chromosome
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Re: The complete sequence of a human Y chromosome
#2Re: The complete sequence of a human Y chromosome
#3This is actually kind of a huge deal since it means that all 24 chromosomes have now been fully sequenced. As it says in the abstract, up until now the Y chromosome proved difficult to sequence due to its nature.
Re: The complete sequence of a human Y chromosome
#4TIL the human Y chromosome hadn't been completely sequenced until now.
Re: The complete sequence of a human Y chromosome
#5For those who don't recall: Back in the Dark Ages, there was a race to decode the human genome. The leading competitiors (wealthiest) were Celera Genomics and the Human Genome Project. After some time, Celera (headed by Craig Venter), announced they had done the deed. However, what Celera had actually done was used what they called a "shotgun method", which meant they took small samples here and there, then built a model of the genome with various statistical shenanigans. About five years later, after all the hype, they admitted they had not sequenced the entire genome.
Ref: https://www.technologyreview.com/2007/09/04/223919/craig-ven...
Re: The complete sequence of a human Y chromosome
#6Could someone explain exactly what it means to be "completely sequence" the human genome when all humans have distinct genetic makeup (ie, different sequences of nucleobases in their DNA/RNA)?
Re: The complete sequence of a human Y chromosome
#7Could someone explain exactly what it means to be "completely sequence" the human genome when all humans have distinct genetic makeup (ie, different sequences of nucleobases in their DNA/RNA)?
I had the same question. Perhaps this will help you.
Re: The complete sequence of a human Y chromosome
#8For a very entertaining and educational book that tangentially related; I can highly recommend: Y - The Descent of Man by Steve Jones [0]
I am thrilled to see more chromosomes being mapped/sequenced. Please excuse my high-school level of biology knowledge here, but have we definitively progressed beyond correlation when it comes to genes, gene expression, and how they all interact?
Take "Blue eyes" as an example, we know that [1] OCA2 is responsible for brown/blue eye colour. BUT are we sure that none of the 20,000 others are involved/needed?
In laymans terms I would guess that to get 'blue eyes' would require several genes to ALL be on/active/present as well. More like a recipe, then a simple on/off it's located in 1 position.
[0] https://www.goodreads.com/work/editions/436071-y-the-descent... [1] https://www.nature.com/articles/s41433-021-01749-x
Re: The complete sequence of a human Y chromosome
#9Could someone explain exactly what it means to be "completely sequence" the human genome when all humans have distinct genetic makeup (ie, different sequences of nucleobases in their DNA/RNA)?
I've never understood this either. I assume the genome is many megabytes of [ATCG]+. If we have that sequence, what does it tell us? Do we look at it and say "Ah, yes, ...ATGCTACGACTACGACTAGCG... very interesting?"
Re: The complete sequence of a human Y chromosome
#10This is actually kind of a huge deal since it means that all 24 chromosomes have now been fully sequenced. As it says in the abstract, up until now the Y chromosome proved difficult to sequence due to its nature.
As others have asked in this thread, what does "fully sequenced" mean to the layman?