Scientists may have found mechanism behind cognitive decline in aging

#1

Post by mdp2021 » Sun, Jul 30, 2023, 8:28 AM UTC

Scientists may have found mechanism behind cognitive decline in aging
news.cuanschutz.edu

Re: Scientists may have found mechanism behind cognitive decline in aging

#2

Post by danielskogly » Sun, Jul 30, 2023, 8:41 AM UTC

Link to paper: https://www.science.org/doi/10.1126/scisignal.ade5892

Re: Scientists may have found mechanism behind cognitive decline in aging

#3

Post by Madmallard » Sun, Jul 30, 2023, 8:50 AM UTC

same mechanism for decline in the rest of the body???? Surely oxidation and dna mutations accumulating affects the brains similarly to how it affects everything else.

Re: Scientists may have found mechanism behind cognitive decline in aging

#4

Post by Etheryte » Sun, Jul 30, 2023, 8:52 AM UTC

...in mice.

Re: Scientists may have found mechanism behind cognitive decline in aging

#5

Post by carrolldunham » Sun, Jul 30, 2023, 8:58 AM UTC

Etheryte wrote: post #4

...in mice.

People just jump to say this like it's a game now. The headline says 'may have found the mechanism'. It's not claiming anything that needs this

Re: Scientists may have found mechanism behind cognitive decline in aging

#6

Post by HeWhoLurksLate » Sun, Jul 30, 2023, 8:59 AM UTC

Madmallard wrote: post #3

same mechanism for decline in the rest of the body???? Surely oxidation and dna mutations accumulating affects the brains similarly to how it affects everything else.

I mean I'm sure that eventually entropy will claim all of us, but it'd be really cool to be able to help people maybe not extend their life times but be less miserable during them

I think I would hate losing my cognitive function if I realized it was slipping away a lot more than needing to use a wheelchair

Re: Scientists may have found mechanism behind cognitive decline in aging

#7

Post by Aaargh20318 » Sun, Jul 30, 2023, 9:01 AM UTC

Etheryte wrote: post #4

...in mice.

Due to the way medication is developed, we basically only end up with medicine that works on humans + at least one other species.

I wonder how many medications we have missed out on that would have worked on humans but never got to the human trial stage because it doesn’t work in any of the animal models we use.

Re: Scientists may have found mechanism behind cognitive decline in aging

#8

Post by MattGaiser » Sun, Jul 30, 2023, 9:04 AM UTC

Etheryte wrote: post #4

...in mice.

Is there any mechanism for a potential medication that has not been discovered first in mice?

Re: Scientists may have found mechanism behind cognitive decline in aging

#9

Post by withinboredom » Sun, Jul 30, 2023, 9:04 AM UTC

Madmallard wrote: post #3

same mechanism for decline in the rest of the body???? Surely oxidation and dna mutations accumulating affects the brains similarly to how it affects everything else.

IIRC, brain cells don’t divide, so “random DNA changes” don’t apply, at least not in the way it would in the rest of the body. I could be totally wrong, I’m not a brain scientist.

Re: Scientists may have found mechanism behind cognitive decline in aging

#10

Post by mdp2021 » Sun, Jul 30, 2023, 9:07 AM UTC

Etheryte wrote: post #4

...in mice.

> Bayer said that aging in mice and humans both decrease a process known as S-nitrosylation, the modification of a specific brain proteins including CaMKII