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RNA editing is common in behaviorally sophisticated coleoid cephalopods (2017)

pubmed.ncbi.nlm.nih.gov

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Re: RNA editing is common in behaviorally sophisticated coleoid cephalopods (2017)

#7
They're cool but they're never taking over the planet. Suckers.

On a more serious note, it's very interesting to see the different mechanisms that nature develops for adaptability.

It seems like there's a trade off here between heredability and adaptability, with cephalopods favouring the second one. Meaning on a long scale their evolution might be slower but it allows them to overcome challenges on the short term more effectively. If I understood correctly, as I haven't read the whole thing yet.

Re: RNA editing is common in behaviorally sophisticated coleoid cephalopods (2017)

#8
> RNA editing, a post-transcriptional process, allows the diversification of proteomes beyond the genomic blueprint; however it is infrequently used among animals for this purpose.

If I had written this and showed it to my PhD advisor, I would have gotten an earful about how "what do you mean by... be specific... what about...", etc. My PI was a nitpicker. Poor fools whose papers had to be edited by him...

That said, RNA splicing is perhaps the single most important RNA editing process in the entire eukaryotic world. And it is so widespread and universally conserved that you can put a human gene in a mouse and it would be spliced the same way. So I don't think RNA editing is something so rare.

Re: RNA editing is common in behaviorally sophisticated coleoid cephalopods (2017)

#9

> RNA editing, a post-transcriptional process, allows the diversification of proteomes beyond the genomic blueprint; however it is infrequently used among animals for this purpose. If I had written this and showed it to my PhD advisor, I would have gotten an earful about how "what do you mean by... be specific... what about...", etc. My PI was a nitpicker. Poor fools whose papers had to be edited by him... That said,…

They split off so long ago that the most recent common ancestor of Cephalopods and mammals is a worm that lived ~500 million years ago:

https://www.researchgate.net/figure/Phylogenetic-tree-depict...

That gives plenty of time for some mechanism to evolve in one of the two branches and not in the other. RNA editing may not be rare in that part of the evolutionary tree but I do wonder if it was already present in that common ancestor.

Re: RNA editing is common in behaviorally sophisticated coleoid cephalopods (2017)

#10

> RNA editing, a post-transcriptional process, allows the diversification of proteomes beyond the genomic blueprint; however it is infrequently used among animals for this purpose. If I had written this and showed it to my PhD advisor, I would have gotten an earful about how "what do you mean by... be specific... what about...", etc. My PI was a nitpicker. Poor fools whose papers had to be edited by him... That said,…

Here RNA editing refers to more discrete changes at specific sequences like A-to-I (Adenosine-to-inosine) substitution. Splicing, capping, tailing, are common but would not be considered editing.
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