Fentanyl vaccine tested in rats
1–10 of 378 posts
Re: Fentanyl vaccine tested in rats
#2This article doesn't mention whether it prevents the cardiovascular depression that actually kills most people exposed to fentanyl. If the vaccine doesn't prevent that, it's useless. A vaccine that makes fentanyl less "fun" doesn't do anything for the people who ingest it thinking that it's something entirely different.
Re: Fentanyl vaccine tested in rats
#3This article doesn't mention whether it prevents the cardiovascular depression that actually kills most people exposed to fentanyl. If the vaccine doesn't prevent that, it's useless. A vaccine that makes fentanyl less "fun" doesn't do anything for the people who ingest it thinking that it's something entirely different.
A vaccine doesn't work unless it helps the tiny fraction of fentenyl deaths who unintentnially take the drug? How about this: You're less likely to come in contact with the drug if there are fewer users getting high off it.
Re: Fentanyl vaccine tested in rats
#4This article doesn't mention whether it prevents the cardiovascular depression that actually kills most people exposed to fentanyl. If the vaccine doesn't prevent that, it's useless. A vaccine that makes fentanyl less "fun" doesn't do anything for the people who ingest it thinking that it's something entirely different.
A vaccine doesn't work unless it helps the tiny fraction of fentenyl deaths who unintentnially take the drug? How about this: You're less likely to come in contact with the drug if there are fewer users getting high off it.
Is there some group of people who are taking fentanyl en masse intentionally?
I know a few people who have died after taking what they thought were bars or ecstasy and died because it was laced with fentanyl. I know 0 who go out of their way to find and take fentanyl.
Re: Fentanyl vaccine tested in rats
#5I can imagine such a thing being a double-edged sword, in that it blocks the analgesic effects of the drug as well as the high. Doubly so if this one is a success and they make similar versions targeting other addictive painkillers.
I can imagine people taking the vaccine proactively (the normal way people think about vaccines, after all) from the perspective of, "I don't want to become an addict, I better take this!" and then later regretting their choice when their options are limited in terms of pain management.
However, if you limit the vaccine to people in recovery, then the harm reduction itself is blunted because the initial adverse event (addiction) has already happened, and this would only affect secondary harms (relapse).
I guess it's better to have more tools in the toolbox, at least, but I'm a bit concerned that these tools might be used injudiciously once they exist.
Re: Fentanyl vaccine tested in rats
#6This article doesn't mention whether it prevents the cardiovascular depression that actually kills most people exposed to fentanyl. If the vaccine doesn't prevent that, it's useless. A vaccine that makes fentanyl less "fun" doesn't do anything for the people who ingest it thinking that it's something entirely different.
A vaccine doesn't work unless it helps the tiny fraction of fentenyl deaths who unintentnially take the drug? How about this: You're less likely to come in contact with the drug if there are fewer users getting high off it.
Let's go another way with this: You are extremely unlikely to ever come across a fentanyl user, even if you work for law enforcement, even if you're a LEO in a major metro.
10x people died of heart attacks than any opioid, not only fentenyl, over the past few years. Almost as many people died of cancer as heart attacks, and half as many people died of COVID as cancer.
Obviously, you can't equate research with other research; research and the drive to do research as a researcher is not a fungible item, but if we're spending tax payer money on it, why not a vaccine for foods that are low in fat, low in sodium, low in nutrition, and high in simple and processed carbs? That could save 700k+ lives a year in the US, more worldwide; and given that is also linked to cancer as the primary driver of it outside of smoking and drinking, another 600k+.
Re: Fentanyl vaccine tested in rats
#7Synthetic depression pill developed just wouldnt have that headline.
Re: Fentanyl vaccine tested in rats
#8This article doesn't mention whether it prevents the cardiovascular depression that actually kills most people exposed to fentanyl. If the vaccine doesn't prevent that, it's useless. A vaccine that makes fentanyl less "fun" doesn't do anything for the people who ingest it thinking that it's something entirely different.
A vaccine doesn't work unless it helps the tiny fraction of fentenyl deaths who unintentnially take the drug? How about this: You're less likely to come in contact with the drug if there are fewer users getting high off it.
Yeah but my understanding is that most of the overdosing are from people seeking something else. In some cases it’s akin to a contamination problem.
Re: Fentanyl vaccine tested in rats
#9This is a good time to remind people that https://twitter.com/justsaysinrats exists for a reason.
... and, indeed, the uh.edu article only tangentially indicates that the actual study (https://www.mdpi.com/1999-4923/14/11/2290/htm) has only been conducted in rats at this time.
Interesting, but since it's brain chemistry we should be wary of getting too excited about the likelihood that this chemical pathway works similarly enough in rats and humans to allow for the drug to be translated (many pathways do! But many don't, and the more complex the system the less likely it translates without deleterious side-effects).
Re: Fentanyl vaccine tested in rats
#10Earlier quoted context omitted.
A vaccine doesn't work unless it helps the tiny fraction of fentenyl deaths who unintentnially take the drug? How about this: You're less likely to come in contact with the drug if there are fewer users getting high off it.
Let's go another way with this: You are extremely unlikely to ever come across a fentanyl user, even if you work for law enforcement, even if you're a LEO in a major metro. 10x people died of heart attacks than any opioid, not only fentenyl, over the past few years. Almost as many people died of cancer as heart attacks, and half as many people died of COVID as cancer. Obviously, you can't equate research with other r…
> Let's go another way with this: You are extremely unlikely to ever come across a fentanyl user, even if you work for law enforcement, even if you're a LEO in a major metro.
I'm gonna need a citation for that outrageous claim
> Obviously, you can't equate research with other research; research and the drive to do research as a researcher is not a fungible item, but if we're spending tax payer money on it, why not a vaccine for foods that are low in fat, low in sodium, low in nutrition, and high in simple and processed carbs? That could save 700k+ lives a year in the US, more worldwide; and given that is also linked to cancer as the primary driver of it outside of smoking and drinking, another 600k+.
Because that is nonsense. We don't have that technology.