Amygdala connectivity predicts ketamine treatment response
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Re: Amygdala connectivity predicts ketamine treatment response
#2Quite interesting .
I have tried ketamine for my PTSD and hasn't worked but stellate gangelion block worked perfectly after just one session .
Re: Amygdala connectivity predicts ketamine treatment response
#3Quite interesting . I have tried ketamine for my PTSD and hasn't worked but stellate gangelion block worked perfectly after just one session .
How long has it worked for?
I googled the procedure and it seems like it's an injection of "anesthetic" to a nerve in the neck. Is that what you're talking about?
Re: Amygdala connectivity predicts ketamine treatment response
#4This is really cool, I think there is a huge opportunity for analysis like this to allow drugs that are currently off market because some small percentage have bad side effects but it works for others. If we can start knowing who drugs will work for and who they won't it could be a game changer for our existing drugs, let alone what we can create in the future
Re: Amygdala connectivity predicts ketamine treatment response
#5Ketamine has turned out to be a pretty effective treatment for episodes of severe depression, particularly when there is a risk of suicide; one reason is that it starts having an effect in hours instead of days or weeks like SSRIs do. See Jessica Gilbert's work over at NIH [1].
One of the big focuses of clinical neuroscience is to find features in the brain that will predict treatment responses (to cognitive behavioral therapy, anti-depressants, and so on).
The amygdala is, as is generally known, strongly associated with fear responses, or other negative emotional responses. The subgenual cingulate cortex has been associated with emotion regulation (e.g. down-regulating responses to negative stimuli). I believe that other treatment-prediction studies have found that connectivity between the subgenual cingulate and other brain regions like the amygdala predict treatment responses, so, their result is pretty consistent with the literature as far as I understand.
1. https://scholar.google.com/citations?user=bSXKfxkAAAAJ&hl=en...
Re: Amygdala connectivity predicts ketamine treatment response
#6Quite interesting . I have tried ketamine for my PTSD and hasn't worked but stellate gangelion block worked perfectly after just one session .
How long has it worked for? I googled the procedure and it seems like it's an injection of "anesthetic" to a nerve in the neck. Is that what you're talking about?
Yes it is . The procedure wasn't really painful just uncomfortable and took about 20 minutes.
I did it about 3 months ago I can't recall exactly.
I was able to find a head and neck doctor that agreed to do it and did it for about 800$.
60 minutes made an episode about it that's when I first knew I had to try it
There are 3 sites that they generally target but I just did right C6 .
Re: Amygdala connectivity predicts ketamine treatment response
#7Ketamine has turned out to be a pretty effective treatment for episodes of severe depression, particularly when there is a risk of suicide; one reason is that it starts having an effect in hours instead of days or weeks like SSRIs do. See Jessica Gilbert's work over at NIH [1]. One of the big focuses of clinical neuroscience is to find features in the brain that will predict treatment responses (to cognitive behavior…
This sounds really promising, but one thing that worries me is that ketamine is a sort-of painkiller (dissociative anesthetic).
When heroin was first discovered, it was hailed as a wonder-drug, and it was also considered an effective treatment for severe depression. However, after some time, people realized that its addictive properties and high range of potential tolerance make it backfire pretty badly after a certain amount of (ab)use.
Can we be sure that a similar thing won't happen with ketamine?
Re: Amygdala connectivity predicts ketamine treatment response
#8Ketamine has turned out to be a pretty effective treatment for episodes of severe depression, particularly when there is a risk of suicide; one reason is that it starts having an effect in hours instead of days or weeks like SSRIs do. See Jessica Gilbert's work over at NIH [1]. One of the big focuses of clinical neuroscience is to find features in the brain that will predict treatment responses (to cognitive behavior…
This sounds really promising, but one thing that worries me is that ketamine is a sort-of painkiller (dissociative anesthetic). When heroin was first discovered, it was hailed as a wonder-drug, and it was also considered an effective treatment for severe depression. However, after some time, people realized that its addictive properties and high range of potential tolerance make it backfire pretty badly after a certa…
Good question.
Ketamine has been a party drug for quite a while now, and as far as I know, hasn't been shown to be particularly dependency-inducing, though low-dose ketamine over the long term might be (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236511/)
Also, as far as I know, ketamine treatment isn't intended as an ongoing medication, like an SSRI, but as a treatment for acute episodes of depression. I might be wrong about that; webmd says, "For treatment-resistant depression, patients usually get the nasal spray twice a week for 1 to 4 weeks; then once a week for weeks 5 to 9; and then once every week or 2 after that." However, the use-cases I know about (from talking to researchers studying it) is as an intervention to prevent suicide during severe depression (since it's relatively fast acting).
As always, its a cost-benefit calculation, that should be carefully made in consultation with a professional. The cost of severe depression can be quite high.
Re: Amygdala connectivity predicts ketamine treatment response
#9Ketamine has turned out to be a pretty effective treatment for episodes of severe depression, particularly when there is a risk of suicide; one reason is that it starts having an effect in hours instead of days or weeks like SSRIs do. See Jessica Gilbert's work over at NIH [1]. One of the big focuses of clinical neuroscience is to find features in the brain that will predict treatment responses (to cognitive behavior…
This sounds really promising, but one thing that worries me is that ketamine is a sort-of painkiller (dissociative anesthetic). When heroin was first discovered, it was hailed as a wonder-drug, and it was also considered an effective treatment for severe depression. However, after some time, people realized that its addictive properties and high range of potential tolerance make it backfire pretty badly after a certa…
From what I've heard ketamine is already (ab)used as a recreational drug since decades back and does have addiction risk.
Not addiction risk anything like heroin though, and the trips are apparently mostly unpleasant.
Ketamine in its present form is decidedly not ideal for depression treatment, but probably a tradeoff often worth considering compared to the risks of severe and enduring depression. Amine neurotransmittor reuptake inhibitors have quite substantial problems associated with them too (there we arguably really have had a case of the mistaken and excessive wonder-drug status you allude to).
The true excitement of ketamine-based depression treatment is perhaps more in that it is something different. It quickly affects the problematic state, by some mechanism which appears to be quite different from the now "classical" antidepressants. That has potential both as a basis for more refined drugs and more importantly to better understand the real mechanisms underpinning depression.
Re: Amygdala connectivity predicts ketamine treatment response
#10Earlier quoted context omitted.
How long has it worked for? I googled the procedure and it seems like it's an injection of "anesthetic" to a nerve in the neck. Is that what you're talking about?
Yes it is . The procedure wasn't really painful just uncomfortable and took about 20 minutes. I did it about 3 months ago I can't recall exactly. I was able to find a head and neck doctor that agreed to do it and did it for about 800$. 60 minutes made an episode about it that's when I first knew I had to try it There are 3 sites that they generally target but I just did right C6 .
Do you plan on repeating it?