Reversing hearing loss with regenerative therapy
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Reversing hearing loss with regenerative therapy
1–10 of 215 posts
Re: Reversing hearing loss with regenerative therapy
#2To be clear, this is FX-322.
Re: Reversing hearing loss with regenerative therapy
#3I have sensoneural hearing loss, mostly in one ear, and the annoying thing about it is hearing aids don't really help much because of the distorted frequencies and non linear loss.
Before I had this I assumed wrongly that hearing loss could always be fixed by making sound louder. (It doesn't, just sounds like a voice disguiser or someone on Helium talking through a bad speaker.)
This looks promising.
Re: Reversing hearing loss with regenerative therapy
#4Disclosure: I own FREQ stock.
The failure of the prior trial was suspected, and I believe it, due to a refractory response by overdosing the inner ear with too frequent administrations of the drug, and then testing for effect too soon. I bet even those candidates of the phase IIa trial though would, if checked on now, show some improvement.
Animal research has shown that natural cochlear hair cell regeneration and resultant hearing restoration is very real, we mammals just don't have the natural cellular signaling to redifferentiate those base cells - small molecule drugs like FX322 do exactly that. I am optimistic they'll eventually find the right dosing regimen to see reliable and optimal clinical effect, and it will be a seismic advance in medicine.
Re: Reversing hearing loss with regenerative therapy
#5Hearing loss is one thing but it's the tinnitus that really bothers me. Hope something that can reverse the damage becomes available in my lifetime.
Re: Reversing hearing loss with regenerative therapy
#6Does anyone know if this can finally be a treatment for tinnitus? I would love to hear silence again.
Re: Reversing hearing loss with regenerative therapy
#7Disclosure: I own FREQ stock. The failure of the prior trial was suspected, and I believe it, due to a refractory response by overdosing the inner ear with too frequent administrations of the drug, and then testing for effect too soon. I bet even those candidates of the phase IIa trial though would, if checked on now, show some improvement. Animal research has shown that natural cochlear hair cell regeneration and re…
Looks like FREQ stock got really beat down over the last few months- any idea what happened was it the negative outcome of the study you mentioned?
Re: Reversing hearing loss with regenerative therapy
#8I have sensoneural hearing loss, mostly in one ear, and the annoying thing about it is hearing aids don't really help much because of the distorted frequencies and non linear loss. Before I had this I assumed wrongly that hearing loss could always be fixed by making sound louder. (It doesn't, just sounds like a voice disguiser or someone on Helium talking through a bad speaker.) This looks promising.
There are some interesting avenues of research for sensorineural hearing loss, such as the non-linearity- and distortion-inducing effects of some psychedelic tryptamines such as DiPT. Psychedelics tend to increase neuroplasticity, and these could do it specifically for aural processing.
Re: Reversing hearing loss with regenerative therapy
#9> Hair cells die off when exposed to loud noises or drugs including certain chemotherapies and antibiotics.
Does this mean this treatment works only for these conditions, and not common aging-related loss?
Re: Reversing hearing loss with regenerative therapy
#10I have sensoneural hearing loss, mostly in one ear, and the annoying thing about it is hearing aids don't really help much because of the distorted frequencies and non linear loss. Before I had this I assumed wrongly that hearing loss could always be fixed by making sound louder. (It doesn't, just sounds like a voice disguiser or someone on Helium talking through a bad speaker.) This looks promising.
My understanding of hearing aids is not that it makes sounds louder across the entire spectrum, but only selective frequencies?
An audiologist should be able to tune your hearing aids to amplify only those frequencies that need amplification.
(Although my understanding is that this is fairly new, and may not be available around the world)