Experimental depression treatment is nearly 80% effective in controlled study
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Re: Experimental depression treatment is nearly 80% effective in controlled study
#2> “The treatment, known as Stanford accelerated intelligent neuromodulation therapy (SAINT) or simply Stanford neuromodulation therapy, is an intensive, individualized form of transcranial magnetic stimulation. In the study, remission typically occurred within days and lasted months. The only side effects were temporary fatigue and headaches.”
> “Twenty-nine people with treatment-resistant depression participated in the study: About half received SAINT, and the rest underwent a placebo procedure that mimicked the real treatment. After five days of treatment, 78.6% of the participants in the treatment group were no longer depressed, according to several standard methods of evaluation. “It’s quite a dramatic effect, and it’s quite sustained,” said Alan Schatzberg, MD, the Kenneth T. Norris, Jr. Professor in Psychiatry and Behavioral Sciences, who was a co-author of the study.”
Makes me wonder what percentage of the placebo group improved?
> The transcranial magnetic stimulation treatment currently approved by the Food and Drug Administration requires six weeks of once-daily sessions. Only about half of patients who undergo the treatment improve, and only about a third experience remission from depression.
Re: Experimental depression treatment is nearly 80% effective in controlled study
#3> “The treatment, known as Stanford accelerated intelligent neuromodulation therapy (SAINT) or simply Stanford neuromodulation therapy, is an intensive, individualized form of transcranial magnetic stimulation. In the study, remission typically occurred within days and lasted months. The only side effects were temporary fatigue and headaches.” > “Twenty-nine people with treatment-resistant depression participated in…
> Within four weeks after treatment, 12 of the 14 participants who had received the treatment improved, and 11 of them met FDA criteria for remission. In contrast, only two of the 15 participants who had received the placebo met the criteria for remission.
Re: Experimental depression treatment is nearly 80% effective in controlled study
#4> “The treatment, known as Stanford accelerated intelligent neuromodulation therapy (SAINT) or simply Stanford neuromodulation therapy, is an intensive, individualized form of transcranial magnetic stimulation. In the study, remission typically occurred within days and lasted months. The only side effects were temporary fatigue and headaches.” > “Twenty-nine people with treatment-resistant depression participated in…
Within four weeks after treatment, 12 of the 14 participants who had received the treatment improved, and 11 of them met FDA criteria for remission. In contrast, only two of the 15 participants who had received the placebo met the criteria for remission
From the article further on.
Re: Experimental depression treatment is nearly 80% effective in controlled study
#5> “The treatment, known as Stanford accelerated intelligent neuromodulation therapy (SAINT) or simply Stanford neuromodulation therapy, is an intensive, individualized form of transcranial magnetic stimulation. In the study, remission typically occurred within days and lasted months. The only side effects were temporary fatigue and headaches.” > “Twenty-nine people with treatment-resistant depression participated in…
The article says 2 out 15 improved in the control group.
Re: Experimental depression treatment is nearly 80% effective in controlled study
#6There are surely enough trials on depression per year that a result with 15 participants in the treatment group is to small to start bringing this to public attention?
With a sample size this small I don't think it should be in the news at all
Re: Experimental depression treatment is nearly 80% effective in controlled study
#7> “The treatment, known as Stanford accelerated intelligent neuromodulation therapy (SAINT) or simply Stanford neuromodulation therapy, is an intensive, individualized form of transcranial magnetic stimulation. In the study, remission typically occurred within days and lasted months. The only side effects were temporary fatigue and headaches.” > “Twenty-nine people with treatment-resistant depression participated in…
For a treatment-resistant condition, 50% success rate can be worth the effort.
Re: Experimental depression treatment is nearly 80% effective in controlled study
#8So the controls got a sham TMS, but not a control location?
Re: Experimental depression treatment is nearly 80% effective in controlled study
#9Link to study PDF: https://ajp.psychiatryonline.org/doi/pdf/10.1176/appi.ajp.20...
Re: Experimental depression treatment is nearly 80% effective in controlled study
#10There are surely enough trials on depression per year that a result with 15 participants in the treatment group is to small to start bringing this to public attention? With a sample size this small I don't think it should be in the news at all
Small sample size, but:
- Building upon mounting evidence of TMS efficacy in patients with severe, intractable depression.
- 79%-- 11 of the 14-- no longer meeting diagnostic criteria for depression after treatment, and another was improved.
- It's an RCT showing both massive efficacy and statistical significance. (2 of 14 in placebo group entered remission).
I know we like to chant "more n"-- but this is very likely to be both real and a clinically useful finding.