Little Exercise, Big Effects: Reversing Aging
jneurosci.org
Little Exercise, Big Effects: Reversing Aging
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Re: Little Exercise, Big Effects: Reversing Aging
#2The 0.7km/week for a house mouse translates to about 7.5 miles/week for a 5'8" tall man compared to a 10cm long mouse. Lots of assumptions, but 7.5 miles is way more than the average sedentary person jogs in a week. It's also very easy to reach for a recreational jogger. Lots of assumptions in there.
Re: Little Exercise, Big Effects: Reversing Aging
#3The 0.7km/week for a house mouse translates to about 7.5 miles/week for a 5'8" tall man compared to a 10cm long mouse. Lots of assumptions, but 7.5 miles is way more than the average sedentary person jogs in a week. It's also very easy to reach for a recreational jogger. Lots of assumptions in there.
And animal models of disease (or aging) are much simpler than real life human biology. One big reason being that lab strains of mice (and maybe the rats in this study, too) are inbred and very homogeneous - genetically speaking. So, something which has a big effect in a lab animal might be due to some strange combination of genes that most "outbred" species (like humans) don't ever have.
Re: Little Exercise, Big Effects: Reversing Aging
#4The HN title gives the impression that they reversed aging. They only reversed changes in memory performance in old mice that are infected with E.coli.
It would be interesting to know how they assessed memory performance - are they using spatial memory tests?
Re: Little Exercise, Big Effects: Reversing Aging
#5For what it's worth, cannabis also prevents neuroinflammation, even in extremely low doses:
http://www.youtube.com/watch?v=2uVXs6CY2ps
http://www.freedomtoexhale.com/clinical.pdf
The endocannabinoid system seems to be the main mechanism our bodies use to naturally regulate inflammation. My understanding is that there is a growing belief among cannabinoid researchers that our cannabinoid receptors can get blocked as we get older, and so there may be a need to either supplement with phytocannabinoids and/or employ various techniques to unmethylate our CB1 receptors. There are a number of folks doing pre-clinical research on cannabinoids as potential treatments for alzheimers and other inflammatory / autoimmune diseases using various cannabinoids.
Here is a cool paper about how colorectal cancer seems to result from the CB1 receptors being knocked out:
http://www.drugs.com/clinical_trials/turned-off-cannabinoid-...
It's possible that most cancers result from the same mechanism, although we don't really know yet. What we do know is that regular marijuana users have a 62% lower chance of head and neck cancers, and that there are an enormous amount of studies showing that cannabinoids can promote both apoptosis (cell death) in cancer cells and are anti-angiogenic, meaning they cut off the blood flow to the tumors.
Re: Little Exercise, Big Effects: Reversing Aging
#6For what it's worth, cannabis also prevents neuroinflammation, even in extremely low doses: http://www.youtube.com/watch?v=2uVXs6CY2ps http://www.freedomtoexhale.com/clinical.pdf The endocannabinoid system seems to be the main mechanism our bodies use to naturally regulate inflammation. My understanding is that there is a growing belief among cannabinoid researchers that our cannabinoid receptors can get blocked as w…
The problem is that I feel less smart and less motivated for 2 weeks after smoking a joint.
Re: Little Exercise, Big Effects: Reversing Aging
#7For what it's worth, cannabis also prevents neuroinflammation, even in extremely low doses: http://www.youtube.com/watch?v=2uVXs6CY2ps http://www.freedomtoexhale.com/clinical.pdf The endocannabinoid system seems to be the main mechanism our bodies use to naturally regulate inflammation. My understanding is that there is a growing belief among cannabinoid researchers that our cannabinoid receptors can get blocked as w…
The problem is that I feel less smart and less motivated for 2 weeks after smoking a joint.
wrong strain?
Re: Little Exercise, Big Effects: Reversing Aging
#8For what it's worth, cannabis also prevents neuroinflammation, even in extremely low doses: http://www.youtube.com/watch?v=2uVXs6CY2ps http://www.freedomtoexhale.com/clinical.pdf The endocannabinoid system seems to be the main mechanism our bodies use to naturally regulate inflammation. My understanding is that there is a growing belief among cannabinoid researchers that our cannabinoid receptors can get blocked as w…
The problem is that I feel less smart and less motivated for 2 weeks after smoking a joint.
[deleted]
Re: Little Exercise, Big Effects: Reversing Aging
#9For what it's worth, cannabis also prevents neuroinflammation, even in extremely low doses: http://www.youtube.com/watch?v=2uVXs6CY2ps http://www.freedomtoexhale.com/clinical.pdf The endocannabinoid system seems to be the main mechanism our bodies use to naturally regulate inflammation. My understanding is that there is a growing belief among cannabinoid researchers that our cannabinoid receptors can get blocked as w…
The problem is that I feel less smart and less motivated for 2 weeks after smoking a joint.
Then don't smoke a joint. The standard sized joints that NIDA hands out for research are 0.7 grams. The amount needed to get this anti-inflammatory effect is roughly .02 grams, in other words 1 / 35th of a joint. There are also two different ways that you can get the same health benefits without any psychoactive side effects. First, you can get high-CBD weed. CBD is a non-psychoactive cannabinoid that basically cancels out the effects of THC. Second, if you juice raw cannabis it is basically non-psychoactive, because without heating or drying it the THCA never gets decarboxylated into THC. Here are a couple articles about this:
Re: Little Exercise, Big Effects: Reversing Aging
#10For what it's worth, cannabis also prevents neuroinflammation, even in extremely low doses: http://www.youtube.com/watch?v=2uVXs6CY2ps http://www.freedomtoexhale.com/clinical.pdf The endocannabinoid system seems to be the main mechanism our bodies use to naturally regulate inflammation. My understanding is that there is a growing belief among cannabinoid researchers that our cannabinoid receptors can get blocked as w…
The problem is that I feel less smart and less motivated for 2 weeks after smoking a joint.
You are starting too early - you have to wait until you're old first.