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Miniaturization and Integration of 3D Printed Microfluidics

rdcu.be

1–10 of 21 posts

Re: Miniaturization and Integration of 3D Printed Microfluidics

#3
I wish the paper included more details on what sort of connectors they use to connect the tubes carrying fluids to the microfluidics chips. Fig.6A shows 9 abstract-looking cylinders, but it's not really clear what's going on there or how it works out. Perhaps the connectors themselves were printed, lending themselves to be easily connected with elastic-tubes -- but you'd have to be super careful when handling those.

Anyway, I do wonder about the feasibility of microfluidics in general. It's become quite popular in recent years (hey, Theranos' whole thing was actually microfluidics!!), but I find lack of blowout successes riding on microfluidics to be something of a concern. I don't know if whether that's because actually delivering with a microfluidics chip takes so much resources that any lab taking on a microfluidics project will then be robbed of resources to work on anything else, or if because orchestrating a dance of small quantities of fluids traversing elaborate pathways here and there at controlled rates, measuring quantities and setting up open feedback loop systems and setting up logic systems is just so hard and that's why I don't hear about happy reportings.

Re: Miniaturization and Integration of 3D Printed Microfluidics

#4
The ui is hot garbage on mobile. No zoom, no visible or hinted access to menus, tiny ass font. It's not clever or attractive. It's a nasty bait and switch - presenting a lure of interesting information, then making it inaccessible in a way that forces the user to waste time trying to figure out how the hell to get at it.

Why do people need to constantly reinvent presentation formats? Literally nobody wants this, it only makes the information harder to view.

This is like a bad flashback to flash Nature is going into the dns blackhole.

Re: Miniaturization and Integration of 3D Printed Microfluidics

#5

The ui is hot garbage on mobile. No zoom, no visible or hinted access to menus, tiny ass font. It's not clever or attractive. It's a nasty bait and switch - presenting a lure of interesting information, then making it inaccessible in a way that forces the user to waste time trying to figure out how the hell to get at it. Why do people need to constantly reinvent presentation formats? Literally nobody wants this, it o…

It took me a few seconds to find the download button though. I actually found it much more convenient than most of other scientific websites.

Re: Miniaturization and Integration of 3D Printed Microfluidics

#6
post #3

I wish the paper included more details on what sort of connectors they use to connect the tubes carrying fluids to the microfluidics chips. Fig.6A shows 9 abstract-looking cylinders, but it's not really clear what's going on there or how it works out. Perhaps the connectors themselves were printed, lending themselves to be easily connected with elastic-tubes -- but you'd have to be super careful when handling those.…

Moderna and BioNTech/Pfizer both depend heavily on microfluidics, I'd call it an amazing success. All sorts of assays and genetic engineering techniques also depend on it.

Re: Miniaturization and Integration of 3D Printed Microfluidics

#7

The ui is hot garbage on mobile. No zoom, no visible or hinted access to menus, tiny ass font. It's not clever or attractive. It's a nasty bait and switch - presenting a lure of interesting information, then making it inaccessible in a way that forces the user to waste time trying to figure out how the hell to get at it. Why do people need to constantly reinvent presentation formats? Literally nobody wants this, it o…

One explanation I can think is the person is not good at making a website. I have my own domain it just has some personal but public to the world stuff about me. It’s a mess of a WordPress site. Some things don’t work on mobile and I’m sure no one wants it lol. I just don’t know how to do it any better. But what I have done was a learning experience for sure. Maybe one day it will be better.

Re: Miniaturization and Integration of 3D Printed Microfluidics

#8
post #7

The ui is hot garbage on mobile. No zoom, no visible or hinted access to menus, tiny ass font. It's not clever or attractive. It's a nasty bait and switch - presenting a lure of interesting information, then making it inaccessible in a way that forces the user to waste time trying to figure out how the hell to get at it. Why do people need to constantly reinvent presentation formats? Literally nobody wants this, it o…

One explanation I can think is the person is not good at making a website. I have my own domain it just has some personal but public to the world stuff about me. It’s a mess of a WordPress site. Some things don’t work on mobile and I’m sure no one wants it lol. I just don’t know how to do it any better. But what I have done was a learning experience for sure. Maybe one day it will be better.

This is the journals pdf viewer not a personal website. Awful design contributes to why more and more academics use Sci-hub out out sheer convenience.

Re: Miniaturization and Integration of 3D Printed Microfluidics

#9
post #3

I wish the paper included more details on what sort of connectors they use to connect the tubes carrying fluids to the microfluidics chips. Fig.6A shows 9 abstract-looking cylinders, but it's not really clear what's going on there or how it works out. Perhaps the connectors themselves were printed, lending themselves to be easily connected with elastic-tubes -- but you'd have to be super careful when handling those.…

These are the type of fitting used in many applications.

https://www.idex-hs.com/store/fluidics/fluidic-connections/f...

They are stupid expensive but usually work well. An alternative is to use a biopsy punch in PDMS and simply shove a 1.6mm tube into the resulting hole. The PDMS will hold the tube securely at most pressures.

Re: Miniaturization and Integration of 3D Printed Microfluidics

#10
post #9
post #3

I wish the paper included more details on what sort of connectors they use to connect the tubes carrying fluids to the microfluidics chips. Fig.6A shows 9 abstract-looking cylinders, but it's not really clear what's going on there or how it works out. Perhaps the connectors themselves were printed, lending themselves to be easily connected with elastic-tubes -- but you'd have to be super careful when handling those.…

These are the type of fitting used in many applications. https://www.idex-hs.com/store/fluidics/fluidic-connections/f... They are stupid expensive but usually work well. An alternative is to use a biopsy punch in PDMS and simply shove a 1.6mm tube into the resulting hole. The PDMS will hold the tube securely at most pressures.

Neat. I see a lot of threaded components, is the expectation that at contact point we should have a threaded opening? How the heck does someone manage to do that at these micro-scales?

Also, wowza, it pains me to see non-metric units used there. One would have thought that fields that are so deeply academic in nature would be free of imperial units!

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