Melatonin may decrease risk for and aid treatment of Covid-19
openheart.bmj.com
Melatonin may decrease risk for and aid treatment of Covid-19
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Re: Melatonin may decrease risk for and aid treatment of Covid-19
#2After 12+ months of suffering, melatonin with high dose nicotinic acid totally cured my long covid.
Re: Melatonin may decrease risk for and aid treatment of Covid-19
#3> A retrospective analysis of 791 intubated patients with COVID-19 has found that, after adjustment for pertinent demographics and comorbidities, those treated with melatonin had a markedly lower risk for mortality (HR: 0.131, 95% CI: 0.076 to 0.223)—suggestive of a profound anti-inflammatory benefit.
> Moreover, recent epidemiology suggests that melatonin usage may reduce the risk for contracting COVID-19. A recent retrospective study, examining data from 26 799 subjects in a COVID-19 registry and using propensity score matching to account for a range of covariates, found that current supplementation with melatonin was associated with a significant 28% reduction in risk for serologically detectible COVID-19 infection. Among Black Americans, this reduction in risk was a remarkable 52% (OR=0.48, 95% CI 0.31 to 0.75).
> More generally, it might be feasible to define a simple nutraceutical regimen that could reduce the risk for COVID-19 and a range of other viral infections. There is growing evidence, both case–control and ecologic, that replete vitamin D status not only markedly improves the clinical course of COVID-19, but also is associated with decreased risk for clinically detectible infection.
> COVID-19 epidemiology also suggests that higher zinc status is associated with both a better clinical course in this disorder and lower risk for infection.42 43 Especially in the elderly, who are more prone to poor zinc status, zinc supplementation has been found to boost acquired, antigen-specific immunity, while also exerting an anti-inflammatory action; such supplementation of the elderly was associated with a marked decrease in total infections in a 12-month randomised controlled trial.
> Hence, it is not unreasonable to suggest that a supplementation programme incorporating vitamin D, zinc, melatonin and possibly additional nutraceuticals could reduce risk for and aid control of COVID-19 and a range of other viral infections.
Re: Melatonin may decrease risk for and aid treatment of Covid-19
#4What if it is not melatonin itself, but the fact that it helps to get more sleep which generally boosts the immune system and has anti-inflamatory effects.
Sleep length/quality should have been taken into account.
Have scientists rediscovered the importance of sleep?
Re: Melatonin may decrease risk for and aid treatment of Covid-19
#5After 12+ months of suffering, melatonin with high dose nicotinic acid totally cured my long covid.
Can you provide proof of this or links to research? Making claims like this is counter productive and only helps to empower the antivaxxers.
Re: Melatonin may decrease risk for and aid treatment of Covid-19
#6What if it is not melatonin itself, but the fact that it helps to get more sleep which generally boosts the immune system and has anti-inflamatory effects. Sleep length/quality should have been taken into account. Have scientists rediscovered the importance of sleep?
Well, we could turn your question around. What if it is not sleep itself, but the fact that it is related to the release of melatonin which potentially mediates immune system responses and inflammation?
The paper offers interesting hypothesis into why this could be the case.
Re: Melatonin may decrease risk for and aid treatment of Covid-19
#7What if it is not melatonin itself, but the fact that it helps to get more sleep which generally boosts the immune system and has anti-inflamatory effects. Sleep length/quality should have been taken into account. Have scientists rediscovered the importance of sleep?
The study is of intubated patients, I think they're asleep a lot...
But I'm sure poor sleep habits are a risk factor for severe Covid anyway.
Re: Melatonin may decrease risk for and aid treatment of Covid-19
#8After 12+ months of suffering, melatonin with high dose nicotinic acid totally cured my long covid.
Can you provide proof of this or links to research? Making claims like this is counter productive and only helps to empower the antivaxxers.
Why do you hate free speech and open discussion?
Why do you hate antivaxxers - are you trained in medicine, molecular biology, etc. or is this nothing more than orthodox ideological position?
The scientific method and science itself is NEVER SETTLED. And it is always advanced from discussion including anecdotes that become more formal research.
Re: Melatonin may decrease risk for and aid treatment of Covid-19
#9After 12+ months of suffering, melatonin with high dose nicotinic acid totally cured my long covid.
Can you give some information or links to what was the dosage and frequency?
Re: Melatonin may decrease risk for and aid treatment of Covid-19
#10After 12+ months of suffering, melatonin with high dose nicotinic acid totally cured my long covid.
Can you provide proof of this or links to research? Making claims like this is counter productive and only helps to empower the antivaxxers.
I totally agree with your point re: the need for data. I would push back a bit on the rhetorical issues with conflating traditional 'antivaxxers' with everyone who may be skeptical of these vaccines. It's not clear that these issues can be meaningfully grouped together on an ontological level.