Study of the effect of Vitamin D, Magnesium and Vitamin B12 on Covid-19 patients
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Re: Study of the effect of Vitamin D, Magnesium and Vitamin B12 on Covid-19 patients
#2N=43 (17 given vitamins vs 26 not)
Highlights:
"Significantly fewer DMB patients than controls required initiation of oxygen therapy subsequently throughout their hospitalization (17.6% vs 61.5%, P=0.006)."
"DMB combination in older COVID-19 patients was associated with a significant reduction in proportion of patients with clinical deterioration requiring oxygen support and/or intensive care support. This study supports further larger randomized control trials to ascertain the full benefit of DMB in ameliorating COVID-19 severity."
So while this is too small of a study to do anything but call for bigger studies, its additional evidence that vitamin deficiency may play a role in COVID-19 severity. Since taking a basic multi-vitamin is good anyway, it seems wise to do that.
Re: Study of the effect of Vitamin D, Magnesium and Vitamin B12 on Covid-19 patients
#3N=43 (17 given vitamins vs 26 not) Highlights: "Significantly fewer DMB patients than controls required initiation of oxygen therapy subsequently throughout their hospitalization (17.6% vs 61.5%, P=0.006)." "DMB combination in older COVID-19 patients was associated with a significant reduction in proportion of patients with clinical deterioration requiring oxygen support and/or intensive care support. This study supp…
> Since taking a basic multi-vitamin is good anyway....
Could you elaborate on that? I thought that taking vitamin supplements without a recommendation from a doctor is just a way to have very expensive piss. Most of the things that get in, are removed from the body without being absorbed.
Re: Study of the effect of Vitamin D, Magnesium and Vitamin B12 on Covid-19 patients
#4N=43 (17 given vitamins vs 26 not) Highlights: "Significantly fewer DMB patients than controls required initiation of oxygen therapy subsequently throughout their hospitalization (17.6% vs 61.5%, P=0.006)." "DMB combination in older COVID-19 patients was associated with a significant reduction in proportion of patients with clinical deterioration requiring oxygen support and/or intensive care support. This study supp…
Despite my somewhat limited knowledge in biology, my intuition was telling me that the number of patients seems way too small to come to definitive conclusions.
Mind you, if Vitamin-D, magnesium and B12 play a role, that's good news for me: I've been very strict about those 3 in the past 2 years(and coincidentally loaded up my magnesium stash yesterday).
Re: Study of the effect of Vitamin D, Magnesium and Vitamin B12 on Covid-19 patients
#5N=43 (17 given vitamins vs 26 not) Highlights: "Significantly fewer DMB patients than controls required initiation of oxygen therapy subsequently throughout their hospitalization (17.6% vs 61.5%, P=0.006)." "DMB combination in older COVID-19 patients was associated with a significant reduction in proportion of patients with clinical deterioration requiring oxygen support and/or intensive care support. This study supp…
Yeah this seems like it'd be much easier to roll out on wide spread basis than HCQ. With an appropriate caution about dosage consulting a doc before making any changes, they're all water soluble.
That there statement about the limits of the study should be taken to heart. People seem to get too fixated on the first results they hear and hold on to them more strongly than subsequent results which can often provide better data to make decisions on.
Re: Study of the effect of Vitamin D, Magnesium and Vitamin B12 on Covid-19 patients
#6N=43 (17 given vitamins vs 26 not) Highlights: "Significantly fewer DMB patients than controls required initiation of oxygen therapy subsequently throughout their hospitalization (17.6% vs 61.5%, P=0.006)." "DMB combination in older COVID-19 patients was associated with a significant reduction in proportion of patients with clinical deterioration requiring oxygen support and/or intensive care support. This study supp…
Despite my somewhat limited knowledge in biology, my intuition was telling me that the number of patients seems way too small to come to definitive conclusions. Mind you, if Vitamin-D, magnesium and B12 play a role, that's good news for me: I've been very strict about those 3 in the past 2 years(and coincidentally loaded up my magnesium stash yesterday).
43 is a reasonable number to start with (it gives you some power wrt sample variance, but you have to pay attention to randomization).
It might give you some information if the intervention were really, really bad for patients or really really good. (So it could be used to establish possible harms). But definitely not useful farther than that except to justify larger studies.
I'm still hoping we catch a break one of these days.
Re: Study of the effect of Vitamin D, Magnesium and Vitamin B12 on Covid-19 patients
#7N=43 (17 given vitamins vs 26 not) Highlights: "Significantly fewer DMB patients than controls required initiation of oxygen therapy subsequently throughout their hospitalization (17.6% vs 61.5%, P=0.006)." "DMB combination in older COVID-19 patients was associated with a significant reduction in proportion of patients with clinical deterioration requiring oxygen support and/or intensive care support. This study supp…
The number of people in the study is too small to really make much in the way of definitive conclusions. But it is certainly enough that a larger study should occur.
In the meantime, since vitamins are cheap and not dangerous at these doses, it seems a reasonable measure to go ahead and take them. They might help, there's weak evidence to suggest that they might, and they shouldn't hurt. However, it's important not to overdose. I know that at least vitamin D is dangerous if overdosed. Most people as they get older are low in vitamin D anyway.
In my mind this is something like masks were months ago. Maybe they help, maybe they don't, but the risk of wearing a mask or taking vitamins is pretty negligible, and there are common-sense reasons to believe they might be helpful. Until better experimental results are available, you should use common sense approaches to reduce your risks. They might not work, but the harm of doing them is negligible.
Re: Study of the effect of Vitamin D, Magnesium and Vitamin B12 on Covid-19 patients
#8Was this known early on about COVID?
Early on in the lockdown I noticed that these vitamins were among the kind of weird items completely cleared out of stores.
People were very selective... initially all FHD laptops and Chromebooks were gone, along with power strips, ibuprofen, hair clippers, etc.
Re: Study of the effect of Vitamin D, Magnesium and Vitamin B12 on Covid-19 patients
#9N=43 (17 given vitamins vs 26 not) Highlights: "Significantly fewer DMB patients than controls required initiation of oxygen therapy subsequently throughout their hospitalization (17.6% vs 61.5%, P=0.006)." "DMB combination in older COVID-19 patients was associated with a significant reduction in proportion of patients with clinical deterioration requiring oxygen support and/or intensive care support. This study supp…
> Since taking a basic multi-vitamin is good anyway.... Could you elaborate on that? I thought that taking vitamin supplements without a recommendation from a doctor is just a way to have very expensive piss. Most of the things that get in, are removed from the body without being absorbed.
If you're deficient in something, your body probably up-regulates absorption.
You can get higher quality vitamins with forms that are more easily absorbed, for example chelated magnesium instead of magnesium oxide.
That said, I thought the evidence actually pointed to higher all cause mortality in people who take vitamins.
Re: Study of the effect of Vitamin D, Magnesium and Vitamin B12 on Covid-19 patients
#10N=43 (17 given vitamins vs 26 not) Highlights: "Significantly fewer DMB patients than controls required initiation of oxygen therapy subsequently throughout their hospitalization (17.6% vs 61.5%, P=0.006)." "DMB combination in older COVID-19 patients was associated with a significant reduction in proportion of patients with clinical deterioration requiring oxygen support and/or intensive care support. This study supp…
Yeah this seems like it'd be much easier to roll out on wide spread basis than HCQ. With an appropriate caution about dosage consulting a doc before making any changes, they're all water soluble. That there statement about the limits of the study should be taken to heart. People seem to get too fixated on the first results they hear and hold on to them more strongly than subsequent results which can often provide bet…
Surely Vitamin D is fat soluble?