Diabetes in mice cured rapidly using human stem cell strategy
medicine.wustl.edu
Diabetes in mice cured rapidly using human stem cell strategy
1–10 of 76 posts
Re: Diabetes in mice cured rapidly using human stem cell strategy
#2Am I assuming correctly that this only applies for type 1 diabetes?
With type 2 diabetes the body is in general less sensitive to insulin, more insulin producing cells won't fix the underlying insensitivity issue, right?
Re: Diabetes in mice cured rapidly using human stem cell strategy
#3Am I assuming correctly that this only applies for type 1 diabetes? With type 2 diabetes the body is in general less sensitive to insulin, more insulin producing cells won't fix the underlying insensitivity issue, right?
Isn't type 2 somewhat reversible by cleaning up diet and a prolonged fast?
Re: Diabetes in mice cured rapidly using human stem cell strategy
#4This reminds me of the time I spent at the NIH conducting research on cancer vaccines. After lots of trial and error, I had finally found something that seemed to prevent lung cancer in mice. I rushed to show my PI the results. He listened intently and asked thoughtful questions. Once I finished, I asked if the findings would be worthy of submitting to Nature.
He looked me straight in the eye and said, “I wouldn’t publish this anywhere, we still have work to do.”
“What do you mean?” I asked.
“If Nature published every article that purported to cure a human disease based on a mouse model, then I would be next in line for the Nobel Prize,” he replied.
Harsh but true. The challenge of curing human disease cannot be replicated in animal models. At least not yet.
Re: Diabetes in mice cured rapidly using human stem cell strategy
#5Am I assuming correctly that this only applies for type 1 diabetes? With type 2 diabetes the body is in general less sensitive to insulin, more insulin producing cells won't fix the underlying insensitivity issue, right?
High blood sugar is toxic to pancreatic beta cells. Thus, poorly controlled type 2 diabetes typically progress to some degree of insulin-dependent diabetes. That condition is the worst of both worlds; your insulin levels are insufficient, but even supplementing insulin artificially can't bring your blood sugar under control without significant lifestyle changes.
Note that beta cells are hardly unique in this regard. High blood sugar is toxic to all tissues, but the affects on some tissues are especially problematic, examples being retinas, kidneys, endothelium, and peripheral nerves.
Re: Diabetes in mice cured rapidly using human stem cell strategy
#6Am I assuming correctly that this only applies for type 1 diabetes? With type 2 diabetes the body is in general less sensitive to insulin, more insulin producing cells won't fix the underlying insensitivity issue, right?
T2D patients also have a reduced amount of insuline-producing beta cells. At diagnosis, there's been a 50% destruction of insuline-producing beta-cells. The destruction progresses with the disease.
Re: Diabetes in mice cured rapidly using human stem cell strategy
#7This reminds me of the time I spent at the NIH conducting research on cancer vaccines. After lots of trial and error, I had finally found something that seemed to prevent lung cancer in mice. I rushed to show my PI the results. He listened intently and asked thoughtful questions. Once I finished, I asked if the findings would be worthy of submitting to Nature. He looked me straight in the eye and said, “I wouldn’t pu…
I stopped counting how many times we cured any forms of diabetes in various mouse models.
Then there is this thing that bugs me: amount of money spent on finding a treatment vs. preventing type 2 diabetes in the first place. Because 95% of type 2 cases are caused by life style decisions. And as climate change, healthcare costs, covid-19, and other self-inflicted societal crises we prefer to wait until it chronically costs a massive amount of money (add chronic deficit to the list).
Re: Diabetes in mice cured rapidly using human stem cell strategy
#8Am I assuming correctly that this only applies for type 1 diabetes? With type 2 diabetes the body is in general less sensitive to insulin, more insulin producing cells won't fix the underlying insensitivity issue, right?
Isn't type 2 somewhat reversible by cleaning up diet and a prolonged fast?
Not sure about a prolonged fast but I had my HbA1c levels at 6.8 (very much diabetic) once and by dropping sugar, white flour, white rice and potatoes and generally eating less (fasting is bad as far as I understand) every check I had since has been 5.3 (very much non-diabetic).
Re: Diabetes in mice cured rapidly using human stem cell strategy
#9This reminds me of the time I spent at the NIH conducting research on cancer vaccines. After lots of trial and error, I had finally found something that seemed to prevent lung cancer in mice. I rushed to show my PI the results. He listened intently and asked thoughtful questions. Once I finished, I asked if the findings would be worthy of submitting to Nature. He looked me straight in the eye and said, “I wouldn’t pu…
I stopped counting how many times we cured any forms of diabetes in various mouse models. Then there is this thing that bugs me: amount of money spent on finding a treatment vs. preventing type 2 diabetes in the first place. Because 95% of type 2 cases are caused by life style decisions. And as climate change, healthcare costs, covid-19, and other self-inflicted societal crises we prefer to wait until it chronically…
It's worth noting that "lifestyle" decisions, are mostly not decisions. They're based on the systemic implications of a person's class, wealth, and status. If a person has more time, and money, and is of a high-enough class, they will be better educated on self-care and health, will have the time to devote to continually ensuring good health, and will have the money to afford high-quality food and activities. Diabetes is a disease of poverty, not of character failure.
Re: Diabetes in mice cured rapidly using human stem cell strategy
#10This reminds me of the time I spent at the NIH conducting research on cancer vaccines. After lots of trial and error, I had finally found something that seemed to prevent lung cancer in mice. I rushed to show my PI the results. He listened intently and asked thoughtful questions. Once I finished, I asked if the findings would be worthy of submitting to Nature. He looked me straight in the eye and said, “I wouldn’t pu…
There was an "...In Mice" meme about this very topic that was even featured here on Hackernews.