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An immune molecule can sometimes influence the social behavior of mice: study

news.mit.edu

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Re: An immune molecule can sometimes influence the social behavior of mice: study

#4
Autistic children are children, the same full irritating, exhuberant, noisy and magnet for troubles in a small package than before, but with a plus of cleverness, strange ways to do things, uncommon hobbies and extravaganza.

The idea that an ill children tired and with less energy than usual would behave better is not a total surprise.

Re: An immune molecule can sometimes influence the social behavior of mice: study

#5
post #2

And vaccines prevent infections. So in other words... :P

My thoughts exactly! That would be a bizarre turn of events.

Not too fast, it goes both ways:

> In 2016, they showed that mice born to mothers who experience a severe infection during pregnancy are much more likely to show behavioral symptoms such as deficits in sociability, repetitive behaviors, and abnormal communication.

Re: An immune molecule can sometimes influence the social behavior of mice: study

#7
> The reason for that, the researchers found, is that in these mice [with certain genes missing and whose mother didn't have inflammation while pregnant], inflammation did not stimulate IL-17a production.

What I wonder if baseline mice produce IL-17a in response to inflammation?

My guess would be no. I would also wonder if some low to moderate infection in mothers can spare the offspring from autism, but still prime IL production?

Re: An immune molecule can sometimes influence the social behavior of mice: study

#8
post #4

Autistic children are children, the same full irritating, exhuberant, noisy and magnet for troubles in a small package than before, but with a plus of cleverness, strange ways to do things, uncommon hobbies and extravaganza. The idea that an ill children tired and with less energy than usual would behave better is not a total surprise.

They say when having fever, the mice communicate with peers better. When children are under the weather, they don't seem to communicate better.

Re: An immune molecule can sometimes influence the social behavior of mice: study

#9
post #2

And vaccines prevent infections. So in other words... :P

> The researchers began by studying mice that exhibited behavioral symptoms due to exposure to inflammation during gestation. They injected these mice with a bacterial component called LPS, which induces a fever response, and found that the animals’ social interactions were temporarily restored to normal.

So if you get your kid sick enough you can temporarily pretend they aren't autistic, and really put to the test the idea that anti-vaxxers think autism is worse than being deathly ill?

Re: An immune molecule can sometimes influence the social behavior of mice: study

#10
post #5

Earlier quoted context omitted.

My thoughts exactly! That would be a bizarre turn of events.

Not too fast, it goes both ways: > In 2016, they showed that mice born to mothers who experience a severe infection during pregnancy are much more likely to show behavioral symptoms such as deficits in sociability, repetitive behaviors, and abnormal communication.

If vaccination of the child could prevent some baseline level of IL-17a from developing (in offsprings who already suffered the brain degradation in the womb), it could be interesting.

They should look for children who had the risk factor (infected mother) but didn't turn autistic to see if they have the levels elevated. Long shot.

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