Breakthrough ultrasound treatment to reverse dementia moves to human trials
1–10 of 43 posts
Re: Breakthrough ultrasound treatment to reverse dementia moves to human trials
#2Is there speculation on what this would do to a healthy brain?
Re: Breakthrough ultrasound treatment to reverse dementia moves to human trials
#3Alzheimer is weird in that plenty of treatment works in mice but fails in humans. I suspect it's primarily because we do not fully understand the cause of Alzheimer.
Re: Breakthrough ultrasound treatment to reverse dementia moves to human trials
#4Is there speculation on what this would do to a healthy brain?
Probably more harm than good- you probably don’t want ultrasonic waves shaking your neurons around without a good reason. This sounds like a “kick a TV and it works again” sort of technology.
Re: Breakthrough ultrasound treatment to reverse dementia moves to human trials
#5Alzheimer is weird in that plenty of treatment works in mice but fails in humans. I suspect it's primarily because we do not fully understand the cause of Alzheimer.
Why do you think that is weird?
My understanding is that "mice studies" cost less than clinical trials, therefore more "mice studies" with (correct/incorrect) conclusions are created.
Re: Breakthrough ultrasound treatment to reverse dementia moves to human trials
#6Wow. This is amazing. My 96-yo grandmother could really try this because anything that could potentially improve her QOL would be good.
Re: Breakthrough ultrasound treatment to reverse dementia moves to human trials
#7Alzheimer is weird in that plenty of treatment works in mice but fails in humans. I suspect it's primarily because we do not fully understand the cause of Alzheimer.
Most likely there is no singular cause, but a slew of contributing factors that prevent amyloid clearance and promote plaque formation. That's why overlapping,
holistic solutions like the Bredesen protocol, ketagenic diets and now possibly ultrasound are the best treatment than waiting for a panacea that is unlikely to ever exist.
Re: Breakthrough ultrasound treatment to reverse dementia moves to human trials
#8Alzheimer is weird in that plenty of treatment works in mice but fails in humans. I suspect it's primarily because we do not fully understand the cause of Alzheimer.
Conversely it would be shocking if most things that work on mice worked in the same ways on humans.
Re: Breakthrough ultrasound treatment to reverse dementia moves to human trials
#9Alzheimer is weird in that plenty of treatment works in mice but fails in humans. I suspect it's primarily because we do not fully understand the cause of Alzheimer.
This is because our mouse models of Alzheimer disease are terrible. And pretty much everything we've tried has been aimed at beta-amyloid.
I think there is a better chance for this therapy because of the way it works, by transition the microglia over to an anti-inflammatory mode.
If this procedure passed safety trials I wouldn't be surprised if a similar therapy worked for schizophrenia, anxiety, and depression.
Re: Breakthrough ultrasound treatment to reverse dementia moves to human trials
#10Is there speculation on what this would do to a healthy brain?
Probably more harm than good- you probably don’t want ultrasonic waves shaking your neurons around without a good reason. This sounds like a “kick a TV and it works again” sort of technology.
Who knows? Maybe certain modes of damage can result in something akin to hypertrophy in muscle?