Increased acidity found in schizophrenia and bipolar patients’ brains
scientificamerican.com
Increased acidity found in schizophrenia and bipolar patients’ brains
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Re: Increased acidity found in schizophrenia and bipolar patients’ brains
#2So after decades of research, and thousands of different markers they could have looked at, they found that pH is a significant marker?
Re: Increased acidity found in schizophrenia and bipolar patients’ brains
#3So after decades of research, and thousands of different markers they could have looked at, they found that pH is a significant marker?
Hard to analyze lots of brains of dead schizoids until we had a methodology to diagnose, permission to analyze them, and then looked closely enough.
http://www.nature.com/mp/journal/v9/n7/full/4001511a.html?fo...
Sometimes lots of theories come out of a minute variation correlation and sometimes it's just a sampling coincidence (like it's just how schizoid brains break down). I'm VERY sure, someone has altered a schizoid's diet to a more or less acidic diet before. I will bet that pH therapy won't be very effective, but it might lead to some other discovery.
Re: Increased acidity found in schizophrenia and bipolar patients’ brains
#4So after decades of research, and thousands of different markers they could have looked at, they found that pH is a significant marker?
That the pH is lower has apparently been known for a while. What's not been clear is the cause of the lower pH and whether the low pH is causing the disorders or if it's just a side effect of an underlying cause or of the medications. This still isn't clear. It could even be a combination of factors, with low pH caused by lactate production stimulating the disorder which increases lactate production... etc.
Re: Increased acidity found in schizophrenia and bipolar patients’ brains
#5So after decades of research, and thousands of different markers they could have looked at, they found that pH is a significant marker?
Not sure what's new 5 years after https://now.uiowa.edu/2012/05/acid-brain (same researcher, pretty much the same conclusions).
Isn't increasing carbon dioxide in the air a standard stress invoking procedure in lab tests on rodents etc?
Re: Increased acidity found in schizophrenia and bipolar patients’ brains
#6So after decades of research, and thousands of different markers they could have looked at, they found that pH is a significant marker?
That the pH is lower has apparently been known for a while. What's not been clear is the cause of the lower pH and whether the low pH is causing the disorders or if it's just a side effect of an underlying cause or of the medications. This still isn't clear. It could even be a combination of factors, with low pH caused by lactate production stimulating the disorder which increases lactate production... etc.
IMO one aspect that isn't well understood enough, and not given enough emphasis in research, are the "cleaning" cycles of the brain. In particular, neuronal autophagy, but also cleaning cycles during sleep. If the overall PH is off, something isn't being cleaned correctly. A byproduct isn't being removed.
I'd love to know how a ten day water fast affects the mental processing and bio-markers of a group of schizophrenia patients. I'd also love to compare their brain activity in a sleep study to that of a control group.
Parallel issues here as with most dementias. Plaques seem to form in all brains, but for most people there are cleaning cycles that break them apart and remove them. With Alzheimer's disease this stops happening. Why?
Another intriguing question for schizophrenia -- eating foods rich in glutamate, for instance rich cheeses, is a negative trigger for many people with schizophrenia. Why? Well, glutamate is metabolized in the brain and it's used as a neurotransmitter. Obviously there is some sort of chemical processing issue in some patients. Figure out what exactly what the issue is and I'd bet you'll know much more about the root cause of Schizophrenia, and potentially several other major mental disorders.
https://www.ncbi.nlm.nih.gov/pubmed/25236722
"Glutamate plays key roles linking carbohydrate and amino acid metabolism via the tricarboxylic acid (TCA) cycle, as well as in nitrogen trafficking and ammonia homeostasis in brain."
"Ammonia homeostasis," sounds like something that might affect PH, right?
Re: Increased acidity found in schizophrenia and bipolar patients’ brains
#7So after decades of research, and thousands of different markers they could have looked at, they found that pH is a significant marker?
Hard to analyze lots of brains of dead schizoids until we had a methodology to diagnose, permission to analyze them, and then looked closely enough. http://www.nature.com/mp/journal/v9/n7/full/4001511a.html?fo... Sometimes lots of theories come out of a minute variation correlation and sometimes it's just a sampling coincidence (like it's just how schizoid brains break down). I'm VERY sure, someone has altered a schi…
>I will bet that pH therapy won't be very effective, but it might lead to some other discovery.
just a note on what therapeutic impact pH therapy have in other situation - mice study on pH therapy (baking soda added to drinking water) for cancer shows at least 2 things - neutralizing tumor pH improves response to other therapies and when alone the pH therapy reduces and slows down metastases formation (at the level of chemotherapy drugs - check out the 2 times difference in survival at the end of 4 month experiment https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2834485/figure/... ).
Re: Increased acidity found in schizophrenia and bipolar patients’ brains
#8Earlier quoted context omitted.
That the pH is lower has apparently been known for a while. What's not been clear is the cause of the lower pH and whether the low pH is causing the disorders or if it's just a side effect of an underlying cause or of the medications. This still isn't clear. It could even be a combination of factors, with low pH caused by lactate production stimulating the disorder which increases lactate production... etc.
IMO one aspect that isn't well understood enough, and not given enough emphasis in research, are the "cleaning" cycles of the brain. In particular, neuronal autophagy, but also cleaning cycles during sleep. If the overall PH is off, something isn't being cleaned correctly. A byproduct isn't being removed. I'd love to know how a ten day water fast affects the mental processing and bio-markers of a group of schizophren…
Weird thing with glutamate though, is that schizphrenics show lowered activation of glutamate which is supposed to be responsible for the negative symptoms of schizophrenia. Things that increase glutamatergic activity(like cycline) help this.
Re: Increased acidity found in schizophrenia and bipolar patients’ brains
#9So after decades of research, and thousands of different markers they could have looked at, they found that pH is a significant marker?
Hard to analyze lots of brains of dead schizoids until we had a methodology to diagnose, permission to analyze them, and then looked closely enough. http://www.nature.com/mp/journal/v9/n7/full/4001511a.html?fo... Sometimes lots of theories come out of a minute variation correlation and sometimes it's just a sampling coincidence (like it's just how schizoid brains break down). I'm VERY sure, someone has altered a schi…
I've never heard someone refer to a schizophrenic as "a schizoid". Schizophrenia and schizoid personality disorder are distinct disorders with different symptoms.
Re: Increased acidity found in schizophrenia and bipolar patients’ brains
#10all this time we thought acid would make you crazy