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Scientists Edge Closer To Lab Test For Chronic Fatigue Syndrome

npr.org

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Re: Scientists Edge Closer To Lab Test For Chronic Fatigue Syndrome

#2
The article is here: http://www.pnas.org/content/early/2017/07/25/1710519114.full...

It's worth noting that their false discovery rate was not study-wide, but rather group-wide. As they state at the very end of the paper, "FDR control was performed separately by group (e.g., severity level) to allow for group differences in the proportions of truly null hypotheses". So, if you try to look at all significant P-values, after adjustment, you'll find that for that purpose, the P-value significance is going to be inflated.

Re: Scientists Edge Closer To Lab Test For Chronic Fatigue Syndrome

#5

The article is here: http://www.pnas.org/content/early/2017/07/25/1710519114.full... It's worth noting that their false discovery rate was not study-wide, but rather group-wide. As they state at the very end of the paper, " FDR control was performed separately by group (e.g., severity level) to allow for group differences in the proportions of truly null hypotheses ". So, if you try to look at all significant P-value…

Also, might be of interest to head over to the supplemental information: http://www.pnas.org/content/suppl/2017/07/25/1710519114.DCSu...

...p. 4 esp: 1) Analysis of ME/CFS Cases vs. Healthy Controls (case versus control means comparisons): We employed pseudo-likelihood ratio testing (8)2 to compare pMFI means between a) each disease severity group versus control and b) the equally-weighted average across all three severity groups versus control.

Re: Scientists Edge Closer To Lab Test For Chronic Fatigue Syndrome

#6
Can I ask an honest, albeit admittedly cynical, question?

In a world run by libertarian capitalists, what good comes from such studies? I know such things can be used to determine policy. But let's say that in turns out cytokines do, in fact, cause CFS, and that -- for the sake of argument -- banning them would be a good thing.

How would this newfound knowledge go from being something known to having action taken upon it? Libertarian capitalism has come to dominate every discussion of this kind. If an action requires regulatory or legislative action, the modern capitalist opposes it outright, even if the outcome would be demonstrably good.

Please forgive if this is off-topic, but it is frustrating seeing such well-done science that seemingly has no one of similar professionalism in the political realm to apply that knowledge in a way that makes society better off.

Re: Scientists Edge Closer To Lab Test For Chronic Fatigue Syndrome

#7
post #6

Can I ask an honest, albeit admittedly cynical, question? In a world run by libertarian capitalists, what good comes from such studies? I know such things can be used to determine policy. But let's say that in turns out cytokines do, in fact, cause CFS, and that -- for the sake of argument -- banning them would be a good thing. How would this newfound knowledge go from being something known to having action taken upo…

That's not so true in Germany, or in Europe in general

Re: Scientists Edge Closer To Lab Test For Chronic Fatigue Syndrome

#8
post #6

Can I ask an honest, albeit admittedly cynical, question? In a world run by libertarian capitalists, what good comes from such studies? I know such things can be used to determine policy. But let's say that in turns out cytokines do, in fact, cause CFS, and that -- for the sake of argument -- banning them would be a good thing. How would this newfound knowledge go from being something known to having action taken upo…

I don't think of myself as a libertarian capitalist, or anything close to that, but I think that being one does not preclude one from playing the long game. One can certainly decide that they will gain maximum profit by investing heavily in research that doesn't have an immediate practical result now, betting on the idea that over time, that research will see a return.

For instance, suppose that the cure for this problem turns out to be an expensive, complex drug. Somebody stands to make a lot of money by figuring out what that drug is and selling it. They can't make that money now, but eventually they'll be able to, so they support the research in order to get there.

Now, do I support profit being the driver behind this kind of research? Not at all. Do I think it's the best system for doing this? Hardly. But can it work? It can and sometimes does.

Re: Scientists Edge Closer To Lab Test For Chronic Fatigue Syndrome

#9
If someone comes to you with a whole lot of pain and loss of function, ignoring it and thinking it's just in their head/they just need to toughen up and get over it because nothing showed up in thier blood reports is something that is almost ubiquitous in the medical field today. I have a connective tissue disorder that was ignored for years because nothing showed up in my blood report and I looked healthy. There is a reason why people are dysfunctional and in pain and once I got a diagnosis from a very highly respected geneticist, every doctor believes you and then they start helping. Otherwise, many just brush you off or worse, perform a surgery and when you keep coming back due to little change in symptoms you get brushed off so you find another doctor, in their minds they successfully treated you and the same cycle continues until you find a doctor who listens and then the treatment essentially starts.

Glad to see CFS sufferers get some validation as they are ignored plenty of times, especially women sufferers.

Note: I would say 40% of my doctors (I've seen over 50) were not like this and about 20% were over the top amazing. Acccesible through phone or email anytime, personally call you after appointments and intermittently to check up, personally call other doctors to explain issues and follow up treatments, extra long appointments.

Basic message: if someone is in pain/unhealthy there is a reason. Rarely it is psychological but that doesn't mean they should not receive adequate treatment and that doesn't mean you place them in that category unless you rule out plenty of other possibilities

Re: Scientists Edge Closer To Lab Test For Chronic Fatigue Syndrome

#10
post #6

Can I ask an honest, albeit admittedly cynical, question? In a world run by libertarian capitalists, what good comes from such studies? I know such things can be used to determine policy. But let's say that in turns out cytokines do, in fact, cause CFS, and that -- for the sake of argument -- banning them would be a good thing. How would this newfound knowledge go from being something known to having action taken upo…

Are you a bot or a real person? How could you ban cytokines? That doesn't even mean anything to the point where I'm not sure you are a human author.
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