Chemical clears Alzheimer's protein and restores memory in mice

#1

Post by coris47 » Thu, Dec 17, 2015, 1:09 PM UTC

Chemical clears Alzheimer's protein and restores memory in mice
nature.com

Re: Chemical clears Alzheimer's protein and restores memory in mice

#2

Post by andy_ppp » Thu, Dec 17, 2015, 2:06 PM UTC

Wow, you can buy some EPPS (the chemical in the article) here for £39.20?

http://www.sigmaaldrich.com/catalog/product/sigma/54465?lang...

Looks interesting research but I'm sure this stuff probably can't be that good for you!

Re: Chemical clears Alzheimer's protein and restores memory in mice

#3

Post by toabi » Thu, Dec 17, 2015, 2:10 PM UTC

andy_ppp wrote: post #2

Wow, you can buy some EPPS (the chemical in the article) here for £39.20? http://www.sigmaaldrich.com/catalog/product/sigma/54465?lang... Looks interesting research but I'm sure this stuff probably can't be that good for you!

Shows 137.50€ here :D

Re: Chemical clears Alzheimer's protein and restores memory in mice

#4

Post by ridgeguy » Thu, Dec 17, 2015, 2:18 PM UTC

andy_ppp wrote: post #2

Wow, you can buy some EPPS (the chemical in the article) here for £39.20? http://www.sigmaaldrich.com/catalog/product/sigma/54465?lang... Looks interesting research but I'm sure this stuff probably can't be that good for you!

Don't have the paper in front of me, but IIRC, the test dose ranged from 10mg/kg to 100mg/kg. A branch of the study looked for adverse effects at 2000mg/kg and found none. That indicates a very large therapeutic margin. Of course it's in mice, not people....

Re: Chemical clears Alzheimer's protein and restores memory in mice

#5

Post by slight » Thu, Dec 17, 2015, 2:20 PM UTC

toabi wrote: post #3

andy_ppp wrote: post #2

Wow, you can buy some EPPS (the chemical in the article) here for £39.20? http://www.sigmaaldrich.com/catalog/product/sigma/54465?lang... Looks interesting research but I'm sure this stuff probably can't be that good for you!

Shows 137.50€ here :D

143.50€ here... (Spain).

Re: Chemical clears Alzheimer's protein and restores memory in mice

#6

Post by plg » Thu, Dec 17, 2015, 2:24 PM UTC

it's a great day for mouse health

Re: Chemical clears Alzheimer's protein and restores memory in mice

#7

Post by eveningcoffee » Thu, Dec 17, 2015, 2:26 PM UTC

The title is "EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques" and it does not say that it reduces memory, it says "EPPS reduces Aβ-aggregate-induced memory deficits in mice" but they also say that "We observed substantial rescue of working memory deficits in Aβ-infused mice by EPPS treatment".

Of course this is only small part of the paper and I have no training to appreciate it more.

Re: Chemical clears Alzheimer's protein and restores memory in mice

#8

Post by codecamper » Thu, Dec 17, 2015, 2:29 PM UTC

slight wrote: post #5

toabi wrote: post #3

Earlier quoted context omitted.

Shows 137.50€ here :D

143.50€ here... (Spain).

158 euro here. (Morocco) maybe a pricing algorithm that increases price based on demand?

Re: Chemical clears Alzheimer's protein and restores memory in mice

#9

Post by wiremine » Thu, Dec 17, 2015, 2:42 PM UTC

plg wrote: post #6

it's a great day for mouse health

You say that tongue in cheek, but as a non-scientist, I've always wondered how much "mouse science" ultimately translates to humans. My guess is it's very low, but knowing a percentage would help me better understand how to proceed reports like this.

Re: Chemical clears Alzheimer's protein and restores memory in mice

#10

Post by deviarte » Thu, Dec 17, 2015, 2:51 PM UTC

toabi wrote: post #3

andy_ppp wrote: post #2

Wow, you can buy some EPPS (the chemical in the article) here for £39.20? http://www.sigmaaldrich.com/catalog/product/sigma/54465?lang... Looks interesting research but I'm sure this stuff probably can't be that good for you!

Shows 137.50€ here :D

$175 here (Netherlands Antilles, Bonaire)