Earlier quoted context omitted.
While the single-threaded execution means that issues from thread interleaving on the scale of nanoseconds will effectively not happen, multiple threads are still allowed and will be context-switched between. rr also has a chaos mode to intentionally make the context switching unfair.
What kind/class of issues are caused by "thread interleaving on the scale of nanoseconds"? Faulty CPU bit flips due to radiation/quantum effects or what are you referring to? Just curious.
With native multithreading data can pass from thread to thread millions of times per second, and you're much less likely to hit obscure interactions when limited instead to maybe a couple hundred context switches per second.