Ask HN: Frighteningly ambitious startup ideas for 2023?

I still find myself re-visiting PG's frighteningly ambitious startup ideas list from 2012. Obviously tech has changed a lot since then. What ideas would you put in an article if you were writing it in 2023?

I looked up the article because I hadn't read it. It's different than what I expected because I was expecting big bets on new things. It's more a list of incumbent (but modern) industries to try disrupting, ie breaking Google's monopoly on search:

http://www.paulgraham.com/ambitious.html