The negative consequence of experience though, in my case, is I'm less excited about new ideas, more skeptic in general, which makes it more difficult to find the motivation that is needed to build something really significant.
And I mean, it's not very surprising, if you haven't made it big at 40+, that means you worked on a lot of failed projects, that makes it harder to believe you can change that.
Maybe some older folks here on HN, but younger people comments welcome too of course, could share their point of view on that question?