Earlier quoted context omitted.
Aren't humans also differentiated from machines in that the latter are designed, while humans are not designed? Machines are just an expression of humans' extended phenotypical effects on their environment.
Is that actually a quantifiable distinction? Does how something is constructed have any affect on it's properties? (assuming equivalent precision of the tools involved) Building a car by hand versus building one with a modern robotic assembly line both yield the same output.
Evolved entities (read: complex entities) are not designed.