My plan: collect my own sperm samples over time and do whole DNA preps + basic body metrics. Sperm regenerates approximately every 10w, so planning time series over 10w. Next, inject myself to ~10x the average amount of microplastics, directly into the bloodstream. Continue with the sperm collection, DNA preps, and basic body metrics. Nanopore sequence, and see if there actually ARE any epigenetic changes. Eventually I'll go back down to baseline - are there any lasting changes?
Of course, this is an N=1 experiment, but rather than a metastudy I'm directly changing one variable, so I think it is valuable. We should have more people doing controlled experiments on themselves for the sake of all of society - and as a biologist, I actually have the capacity to design the experiments and scientifically interpret the results. In a way, it's part of civic duty :)