WASM - Mostly as a compile target for Rust, but I think this changes the way software might be deployed. No longer as a website, but as a binary distributed across CDNs.
ZK-SNARKS - Zero knowledge proofs are still nascent, but being able to prove you know something while not revealing what it is has specific applicability for outsourcing computation. It's a dream to replace cloud computing as we know it today.
Lightning Network - A way to do micropayments, if it works, will be pretty interesting.
BERT - Newer models for NLP are always interesting because the internet is full of text.
RoamResearch - The technology for this has been around for a while, but it got put together in a interesting way.
Oculus Quest - Been selling out during COVID. I sense a behavioral change.
Datomic - Datalog seems to be having a resurgence. I wonder if it can fight against the tide of editing in-place.