Embarrassed to say that I wasn't aware of this practice. Are there malicious uses for this beyond fingerprinting?
https://files.catbox.moe/g1bejn.png When I visit the site from Safari on macOS I see this in the console. Are there any particular services that use port 8888 for the website to do this?
It seems to be part of some "bot defense" product by these F5 people, to "test the different browser capabilities". I doubt it's intended to hit a real endpoint on any system.